Publications by authors named "Thomas Senecal"
Article Synopsis
- Iron regulatory proteins (Irps) 1 and 2 manage the expression of genes related to iron metabolism, affecting key proteins like ferritin and transferrin receptor.
- Mice lacking Irp1 showed severe health issues like pulmonary hypertension and increased red blood cell counts, especially when on a low-iron diet.
- The absence of Irp1 led to elevated HIF2α levels, which resulted in more erythropoietin production and related complications, illustrating the crucial role of Irp1 in iron regulation and its impact on respiratory and blood health.
The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes. We previously demonstrated that FPN1 was highly expressed in erythroblasts, a cell type that consumes most of the serum iron for use in hemoglobin synthesis. Herein, we have demonstrated that FPN1 localizes to the plasma membrane of erythroblasts, and hepcidin treatment leads to decreased expression of FPN1 and a subsequent increase in intracellular iron concentrations in both erythroblast cell lines and primary erythroblasts.
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