Publications by authors named "Thomas Schmitz-Rixen"

Article Synopsis
  • - The study explores how circadian rhythms, seasonal changes, and weather conditions may impact thromboembolic events specifically related to popliteal artery aneurysms (PAA), as data was gathered from a German PAA registry and meteorological service.
  • - Among the 1,200 cases analyzed, there were more symptomatic PAA patients in the first half of the year, particularly with symptoms appearing frequently in the morning; this suggests a seasonal and temporal pattern to their condition.
  • - The research revealed a correlation between temperature drops and symptom onset, with older patients showing less sensitivity to temperature changes, highlighting a need for further study on how weather influences these vascular events.
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Objective: Analysis of gender-specific differences in short- and long-term outcome after elective open abdominal aortic aneurysm repair (OAR) regarding the distal anastomosis.

Methods: In this retrospective cohort study, data from 4853 patients of a German health insurance company undergoing OAR for infrarenal abdominal aortic aneurysms (AAAs) between 2010 and 2016 were analysed. The patients were followed through 2018.

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The Basic Vascular Science (BVS) meeting was set up to provide a forum for researchers and clinicians in the field to exchange knowledge and ideas and to foster cross-disciplinary collaborations. The BVS 2024 meeting was held in Berlin. Attended by vascular surgeons and physicians, interventional radiologists, basic science researchers, and engineers, the meeting continues to successfully attract both early career researchers and established clinician-scientists.

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Background: The aim of this study is to present short- and long-term outcomes after lower extremity bypass (LEB) surgery in patients with chronic limb-threatening ischemia and chronic kidney disease (CKD), differentiated by peripheral artery disease (PAD) Fontaine stage III and IV.

Methods: Retrospective analysis of anonymized data from a nationwide German health insurance company (AOK). Data from 22,633 patients (14,523 men) who underwent LEB from 2010 to 2015 were analyzed, presenting 18,271 with CKD stage 1/2, 2,483 patients with CKD stage 3, and 1,879 with CKD stage 4/5.

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Article Synopsis
  • - The S2k guideline on venous leg ulcers was developed by a collaborative group led by the German Society of Phlebology and Lymphology, including various other German medical societies.
  • - The goal is to unify different medical approaches to create a comprehensive treatment framework for venous leg ulcers, benefiting both patients and healthcare professionals.
  • - It includes 70 specific recommendations across key areas like diagnostics, therapy, prevention of recurrences, and everyday challenges, reflecting the latest scientific knowledge for clinical practice.
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A growing body of evidence highlights the effects of air pollution on chronic and acute cardiovascular diseases, such as associations between PM and several cardiovascular events. However, evidence of the impact of fine air pollutants on the development and progression of peripheral arterial aneurysms is not available. Data were obtained from the multicenter PAA outcome registry POPART and the German Environment Agency.

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Background: Popliteal artery aneurysms (PAAs) are the most common peripheral aneurysm. However, due to its rarity, the cumulative body of evidence regarding patient patterns, treatment strategies, and perioperative outcomes is limited. This analysis aims to investigate distinct phenotypical patient profiles and associated treatment and outcomes in patients with a PAA by performing an unsupervised clustering analysis of the POPART (Practice of Popliteal Artery Aneurysm Repair and Therapy) registry.

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Article Synopsis
  • - The advancements in treating abdominal aortic aneurysms over the last 15 years have led to the need for a reassessment of the quality assurance guidelines for nursing personnel training in intensive care in Germany, which currently mandates a 50% specialist training quota that lacks empirical backing.
  • - A diverse group of 37 experts participated in a modified Delphi process involving literature searches, surveys, and discussions to assess and redefine training quotas for nursing staff, ultimately reaching a consensus.
  • - The expert panel recommended lowering the required specialist training quota to 30% and emphasized the need for structured programs to maintain and elevate nursing staff qualifications in intensive care units managing abdominal aortic aneurysms.
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Aim: To present the short- and long-term outcomes of lower extremity bypass (LEB) surgery in patients with critical limb-threatening ischaemia (CLTI), comparing diabetic (DM) and non-diabetic (non-DM) patients.

Methods: Retrospective analysis of anonymised data from a nationwide health insurance company (AOK). Data from 22,633 patients (DM: = 7266; non-DM: = 15,367; men: = 14,523; women: = 8110; mean patient age: 72.

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Article Synopsis
  • The study focuses on the treatment and outcomes of popliteal artery aneurysms (PAAs) in women, who make up only 5% of PAA patients, highlighting the lack of extensive evidence in this area.
  • Data was collected from the POPART Registry, a large European registry involving 42 centers, examining clinical presentation and surgical outcomes since 2010.
  • Findings revealed that female patients had smaller aneurysms and higher rates of symptoms before surgery, along with increased complications like impaired wound healing and the need for additional procedures post-surgery compared to men.
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Background: In Germany, there is no data available on the frequency of inpatient rehabilitation (IR) after elective endovascular (EVAR) and open (OAR) abdominal aortic aneurysm (AAA) repair.

Objective: To report for the first time on the outcome of patients 65 years and older and thus of retirement age with and without IR after AAA repair in a retrospective analysis of routine data from all eleven regional companies of the AOK health insurance fund (AOK-Gesundheit).

Methods: Anonymized data of 16,358 patients 65 years and older with intact abdominal aortic aneurysm treated with EVAR (n = 12,960) or OAR (n = 3,398) between 01/01/2010 and 12/31/2016 were analyzed.

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Purpose: The influence of cancer development on long-term outcome after lower extremity bypass surgery in patients with critical limb threatening ischemia was investigated.

Methods: Patient survival and cancer incidence were recorded for 21,082 patients with peripheral artery disease (PAD) stage III (n = 5631; 26.7%) and stage IV (n = 15,451; 73.

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Fachkliniken spielen in der stationären Versorgung im deutschen Gesundheitswesen eine wesentliche Rolle. Sie zeichnen sich durch eine hohe Spezialisierung und Expertise aus und werden in zahlreichen medizinischen Disziplinen beschrieben. Allerdings fehlt bisher eine allgemein akzeptierte Legaldefinition von Fachkliniken.

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Background: Heterogeneity regarding dosimetry and reporting of endovenous laser ablation (EVLA) mandates the development of a standardized protocol. This study presents the mid-term results of EVLA with 1940 nm-laser and radial-fibre, supported by a four-zone dosimetry tool.

Materials And Methods: Four anatomical dosimetry zones for great saphenous veins (GSV) and two for small saphenous veins (SSV) were defined with set power levels.

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Background: Having cancer adversely effects the outcome of treatment for an unruptured abdominal aortic aneurysm (AAA).

Methods: A retrospective secondary analysis was performed on the basis of anonymized data from AOK, a German nationwide statutory healthinsurance carrier. Data were evaluated from all of the 20 683 patients who underwent either endovascular (EVAR, 15 792) or open surgical (OAR, 4891) treatment for an unruptured AAA in the years 2010-2016.

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Objective: Endovascular aortic aneurysm repair (EVAR) has been established as a standard treatment option for intact abdominal aortic aneurysm (iAAA) and gained importance due to a lower perioperative mortality than open repair (OAR). However, whether this survival advantage can be maintained or if OAR is beneficial in terms of long-term complications and reinterventions remains questionable.

Design: In this retrospective cohort study data from patients undergoing elective EVAR or OAR for iAAAs in the years 2010-2016 was analyzed.

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Background: This retrospective propensity score matched study presents the perioperative mortality and long-term survival up to 9 years after endovascular (EVAR) and open (OAR) repair of patients with ruptured abdominal aortic aneurysm (rAAA) in Germany using health insurance data.

Materials And Methods: 2170 patients treated between January 1st, 2010 and December 31st, 2016, for rAAA within 24 hours of hospital admission and receiving blood transfusions were enrolled in the study and tracked until December 31st, 2018. For better comparability of EVAR and OAR, a 1:1 propensity score matching with 624 pairs according to patient age, sex and comorbidities was carried out using the R program (Foundation for Statistical Computing, Vienna, Austria).

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To report technical success as well as perioperative outcomes of patients who underwent endovascular aortic repair (EVAR) of penetrating abdominal aortic ulcers ≤35 mm in diameter (PAU). The abdominal aortic aneurysm (AAA) quality registry of the German institute for vascular research (DIGG) was used to identify patients with standard EVAR for infrarenal PAU ≤35 mm between 1/1/2019 and 12/31/2021. Infectious, traumatic, inflammatory PAUs, PAUs associated with connective tissue disease, PAUs following aortic dissection as well as true aneurysms were excluded.

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Objectives: The analysis of wall strain opens new perspectives in the prediction of abdominal aortic aneurysm (AAA) rupture. This study investigates the capability of four-dimensional ultrasound (4D US) to detect and characterize changes in wall strain in the same patients during follow-up observations.

Methods: Eighteen patients were examined by 64 4D US scans during a median follow-up period of 24.

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Article Synopsis
  • The study looked at how male and female patients with abdominal aortic aneurysms (AAA) respond to treatment and found that women tend to have worse outcomes than men.
  • It analyzed data from thousands of patients to compare factors like aneurysm size and how they relate to the risk of dying after surgery.
  • The results showed that even though women had smaller aneurysms, they had higher death rates after 30 days of surgery compared to men.
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Article Synopsis
  • The study aimed to compare patients with multiple arterial aneurysms to those with single aneurysms, focusing on factors like age, sex, and location of the aneurysms.
  • Out of 3107 patients reviewed, 2189 were included, with 143 having multiple aneurysms and a significant difference in average age at diagnosis between the two groups.
  • Findings revealed that patients with multiple aneurysms were generally younger and had different common locations for their aneurysms, confirmed by a follow-up study at another institution.
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In the past two decades, endovascular aortic repair (EVAR) of abdominal aortic aneurysm (AAA) has become the first line treatment for infrarenal AAA repair in many countries. While short-term results are good, concerns have been raised about long-term durability. Changes in aortoiliac anatomy, especially at the landing zones, could play a role in EVAR failure over time.

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Background: Walking is the preferred therapy for peripheral arterial disease in early stage. An effect of walking exercise is the increase of blood flow and fluid shear stress, leading, triggered by arteriogenesis, to the formation of collateral blood vessels. Circulating micro-RNA may act as an important information transmitter in this process.

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