Publications by authors named "Thomas S Kouyate"
Front Immunol
October 2024
Article Synopsis
- Early life adaptations in immune system function are crucial for infant health, with newborns facing environmental challenges that test their immune response.
- Adenosine deaminases (ADAs), specifically ADA-1 and ADA-2, play important roles in immune modulation, and infants typically show lower ADA activity, resulting in higher levels of plasma adenosine and an anti-inflammatory bias.
- A study comparing plasma ADA activity in infants from Papua New Guinea to those from The Gambia found that PNG infants had lower ADA levels at birth but these levels increased and converged by the one-month mark, highlighting the importance of genetic and environmental factors in immune development.
