Reconstruction of full thickness lower eyelid defects using a lateral advancement flap with Z-plasty and periosteal strip.

Purpose: To describe a single stage technique of reconstruction of full thickness lower eyelid defects using a lateral advancement flap and Z-plasty combined with a lateral periosteal strip.

Methods: A retrospective case series of six patients who underwent reconstruction using this technique is presented documenting surgical technique, clinical photographs and postoperative outcomes.

Results: All six patients demonstrated good eyelid position and cosmesis following reconstruction.

Bisphosphonate-Induced Orbital Inflammation: A Case Series and Review.

Introduction: To present a series of patients with bisphosphonate induced orbital inflammation, and to review the clinical presentation, radiological features, treatment options and outcomes.

Methods: We present a multicentre, retrospective case series review of patients with a clinico-radiological diagnosis of bisphosphonate induced orbital inflammation and review all the reported cases of this complication in the literature.

Results: Four new patients with bisphosphonate induced orbital inflammation were added to the 25 cases in the literature.

The dexamethasone suppression test for the diagnosis of Cushing syndrome in a patient with central serous chorioretinopathy.

Purpose: To describe a case whereby the dexamethasone suppression test was used to diagnose Cushing syndrome in a patient presenting with central serous chorioretinopathy.

Methods: A 60-year-old woman presented with central serous chorioretinopathy and was investigated with the dexamethasone suppression test; the result was positive and lead to a diagnosis of an adrenal tumor.

Results: The adrenal tumor was removed and her central serous chorioretinopathy resolved.

In vitro effects of histone deacetylase inhibitors and mitomycin C on tenon capsule fibroblasts and conjunctival melanoma cells.

Objective: To investigate the effects of mitomycin C and the histone deacetylase inhibitors sodium butyrate and trichostatin on the viability and growth of conjunctival melanoma cell lines and Tenon capsule fibroblasts.

Methods: Cells were treated with a range of concentrations of sodium butyrate, trichostatin, and mitomycin C. The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assays were performed 48 hours after treatment.

Lung metastases in a case of metatypical basal cell carcinoma of the eyelid: an illustrative case and literature review to heighten vigilance of its metastatic potential.

Basal cell carcinoma (BCC) is an extremely common malignancy; however, unlike other skin cancers, they very rarely metastasize. Here we present an unusual case of metatypical BCC of the eyelid which metastasized to the lung nine years after initial surgical treatment. We include a review of the literature regarding metastatic BCC and suggest that metatypical features in primary BCC should prompt careful patient monitoring and consideration of adjuvant treatment at the time of diagnosis.