Latanoprost Induced Iris Pigment Epithelial and Ciliary Body Cyst Formation in Hypermetropic Eyes.

Purpose: Latanoprost has become one of the most widely prescribed topical antihypertensive medications in recent years. Yet there have been few reports of secondary iris pigment epithelial (IPE) and ciliary body (CB) cyst formation to date and none, to our knowledge, reported in eyes predisposed to primary angle closure.

Methods: We report the first documented case of bilateral IPE and CB cysts in a hypermetropic patient with prior laser peripheral iridotomies (LPIs) as a rare, delayed side effect of topical Latanoprost treatment.

Scleral perforation after trans-scleral cyclodiode laser for intraocular pressure reduction.

Herein a case is reported of a full-thickness scleral burn in the left eye of a 61-year-old man, following contact trans-scleral cyclodiode laser treatment for traumatic aphakic glaucoma, unresponsive to maximal medical treatment. The defect was successfully repaired by scleral suturing under local anaesthetic.

Intraocular lens pupillary capture after neodymium:YAG laser treatment of interlenticular opacification of posterior chamber piggyback intraocular lenses.

A hyperopic 73-year-old woman had bilateral phacoemulsification with primary implantation of piggyback AcrySof intraocular lenses (IOLs) (Alcon) in the capsular bag. Interlenticular opacification (ILO) developed after 6 months in the left eye and after 2 years in the right eye. Treatment of the ILO in the left eye with a neodymium:YAG (Nd:YAG) laser resulted in pupillary capture of the optic of the anterior IOL.

Imaging of metastatic orbital leiomyosarcoma.

A 74-year-old man with a previous history of lower leg soft tissues leiomyosarcoma and multiple metastasis presented with a progressive painless proptosis of the left eye. Orbital ultrasound, CT, and MRI revealed a large mass in the left medial orbit. The mass was surgically removed and pathologic examination confirmed the diagnosis of a metastatic orbital leiomyosarcoma.

A polymorphism at codon 31 of gene p21 is not associated with primary open angle glaucoma in Caucasians.

Background: Primary open angle glaucoma (POAG) is considered to be a neurodegenerative optic neuropathy, in which cell death occurs by apoptosis. p21, is an important protective component of the apoptotic pathway, regulating cellular arrest in the presence of DNA damage. An unstable or altered p21 protein could modify the cellular response to genomic injury and abolish the effect of p21.

Clinical outcome of endonasal KTP laser assisted dacryocystorhinostomy.

Background: To evaluate the clinical outcome of primary endonasal laser assisted dacryocystorhinostomy (ENL-DCR) using the potassium-titanyl-phosphate laser.

Methods: We retrospectively reviewed all primary ENL-DCRs performed within a period of twelve months by the same combined Ophthalmology and Otorhinolaringology team in Freeman Hospital, Newcastle upon Tyne, UK. The main outcome measure for success was resolution or significant improvement of epiphora.

Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma.

Purpose: Primary open angle glaucoma (POAG) is a major cause of late onset visual failure of unknown etiology. Recent genetic association studies have implicated the apolipoprotein E (APOE) gene in the pathophysiology of primary open angle glaucoma, but there have been conflicting findings.

Methods: To resolve this issue we studied 140 cases and 73 controls that were carefully phenotyped, and used a logistic regression model to simultaneously analyze the effect of apolipoprotein E genotype and functional polymorphisms in the apolipoprotein E gene promoter while controlling for potentially confounding variables.

The role of apolipoprotein E gene polymorphisms in primary open-angle glaucoma.

Objective: To test the hypothesis that genetic polymorphisms of the apolipoprotein E (APOE) gene are associated with primary open-angle glaucoma (POAG), based on the association between neurodegenerative diseases and the APOE genotype.

Methods: Genomic DNA was examined from an unrelated cohort of 137 POAG patients and 75 control subjects from the ophthalmology department of the Royal Victoria Infirmary. The APOE allele frequency (epsilon2, epsilon3, and epsilon4 alleles) was studied by polymerase chain reaction amplification of the related locus (19q13.

Improved illumination for the Perkins applanation tonometer.

Aims: To improve the Perkins tonometer measurements by using an augmented, monochromatic solid-state light source of 470 nm wavelength.

Methods: This prospective study comprised 44 patients of our ophthalmic department who were split into two groups of 21 and 23 patients, and were tested by two independent ophthalmologists. Intraocular pressure (IOP) was measured in both eyes, comparing the instrument with augmented source against the standard Perkins for both observers.