Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes.

A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.

Delayed and non-union of the humeral diaphysis--compression plate or internal plate fixator?

In a retrospective study, two groups of patients with delayed or non-union of the humeral diaphysis were compared. In group A, a 4.5-mm low-contact dynamic compression plate (LCDCP) was used for internal fixation and in group B, an internal plate fixator with locked screws was used.