Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease.

The survival factor renalase (RNLS) is a recently discovered secretory protein with potent prosurvival and anti-inflammatory effects. Several evolutionarily conserved RNLS domains are critical to its function. These include a 20 aa site that encodes for its prosurvival effects.

Anal adenocarcinoma: case report, literature review and comparative survival analysis.

Introduction: Anal adenocarcinoma is a rare malignancy with a poor prognosis.

Methods: We present a case of rare anal adenocarcinoma in a patient with normal screening colonoscopy. Using the Surveillance, Epidemiology and End Result database between 2000 and 2016, we performed survival analysis among individuals>20 years old comparing anal and rectal cancers.