Thanks to recent progress in cancer research, most children treated for cancer survive into adulthood. Nevertheless, the long-term consequences of anticancer agents are understudied, especially in the pediatric population. We and others have shown that routinely administered chemotherapeutics drive musculoskeletal alterations, which contribute to increased treatment-related toxicity and long-term morbidity.
View Article and Find Full Text PDFIntroduction: Thrombotic events in neonates and children represent a rare although severe occurrence in view of the associated risk of mortality and sequelae. Quality evidence is limited in this field, and registry studies provide an essential base for research. The aim of this paper is to present the new Italian Registry of Infantile Thrombosis (RITI), set it into the scene of international thrombosis and stroke registries, and provide some insight on the challenges associated with registry management.
View Article and Find Full Text PDFThe glutamate metabotropic receptor 4 () locus is linked to susceptibility to human osteosarcoma, through unknown mechanisms. We show that gene-targeted mice demonstrate accelerated radiation-induced tumor development to an extent comparable with mice. GRM4 is expressed in myeloid cells, selectively regulating expression of IL23 and the related cytokine IL12.
View Article and Find Full Text PDFEur Phys J C Part Fields
January 2019
[This corrects the article DOI: 10.1140/epjc/s10052-017-4819-4.].
View Article and Find Full Text PDFA measurement of the mass of the boson is presented based on proton-proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to of integrated luminosity. The selected data sample consists of candidates in the channel and candidates in the channel. The -boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the boson transverse mass in the electron and muon decay channels, yielding where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty.
View Article and Find Full Text PDFThe modification of the production of , , and ( ) in +Pb collisions with respect to their production in collisions has been studied. The +Pb and datasets used in this paper correspond to integrated luminosities of and respectively, collected in 2013 and 2015 by the ATLAS detector at the LHC, both at a centre-of-mass energy per nucleon pair of 5.02 TeV.
View Article and Find Full Text PDFEur Phys J C Part Fields
February 2018
A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of collisions corresponding to an integrated luminosity of 36.1 fb , recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV.
View Article and Find Full Text PDFEur Phys J C Part Fields
May 2018
The results of a search for new heavy bosons decaying to an electron or muon and a neutrino using proton-proton collision data at a centre-of-mass energy of TeV are presented. The dataset was collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 36.1 .
View Article and Find Full Text PDFEur Phys J C Part Fields
November 2018
The performance of the missing transverse momentum ( ) reconstruction with the ATLAS detector is evaluated using data collected in proton-proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015. To reconstruct , fully calibrated electrons, muons, photons, hadronically decaying , and jets reconstructed from calorimeter energy deposits and charged-particle tracks are used. These are combined with the soft hadronic activity measured by reconstructed charged-particle tracks not associated with the hard objects.
View Article and Find Full Text PDFEur Phys J C Part Fields
December 2018
A search for the electroweak production of charginos, neutralinos and sleptons decaying into final states involving two or three electrons or muons is presented. The analysis is based on 36.1 fb of TeV proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider.
View Article and Find Full Text PDFPhys Rev Lett
November 2017
Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb[over ¯] pair with the ATLAS detector using 36.1 fb^{-1} of pp collisions at a center-of-mass energy of 13 TeV at the LHC.
View Article and Find Full Text PDFA search for heavy pseudoscalar (A) and scalar (H) Higgs bosons decaying into a top quark pair (tt[over ¯]) has been performed with 20.3 fb^{-1} of proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a center-of-mass energy sqrt[s]=8 TeV. Interference effects between the signal process and standard model tt[over ¯] production, which are expected to distort the signal shape from a single peak to a peak-dip structure, are taken into account.
View Article and Find Full Text PDFEur Phys J C Part Fields
June 2017
Multi-particle cumulants and corresponding Fourier harmonics are measured for azimuthal angle distributions of charged particles in [Formula: see text] collisions at [Formula: see text] = 5.02 and 13 TeV and in [Formula: see text] + Pb collisions at [Formula: see text] = 5.02 TeV, and compared to the results obtained for low-multiplicity [Formula: see text] collisions at [Formula: see text] = 2.
View Article and Find Full Text PDFEur Phys J C Part Fields
May 2017
Measurements of the production cross section of a [Formula: see text] boson in association with jets in proton-proton collisions at [Formula: see text] TeV are presented, using data corresponding to an integrated luminosity of 3.16 fb[Formula: see text] collected by the ATLAS experiment at the CERN Large Hadron Collider in 2015. Inclusive and differential cross sections are measured for events containing a [Formula: see text] boson decaying to electrons or muons and produced in association with up to seven jets with [Formula: see text] GeV and [Formula: see text].
View Article and Find Full Text PDFWith the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 [Formula: see text] for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.
View Article and Find Full Text PDFA search for the dimuon decay of the Higgs boson was performed using data corresponding to an integrated luminosity of 36.1 fb^{-1} collected with the ATLAS detector in pp collisions at sqrt[s]=13 TeV at the Large Hadron Collider. No significant excess is observed above the expected background.
View Article and Find Full Text PDFEur Phys J C Part Fields
August 2017
Detailed measurements of -channel single top-quark production are presented. They use 20.2 fb[Formula: see text] of data collected by the ATLAS experiment in proton-proton collisions at a centre-of-mass energy of 8 TeV at the LHC.
View Article and Find Full Text PDFThe reconstruction of the signal from hadrons and jets emerging from the proton-proton collisions at the Large Hadron Collider (LHC) and entering the ATLAS calorimeters is based on a three-dimensional topological clustering of individual calorimeter cell signals. The cluster formation follows cell signal-significance patterns generated by electromagnetic and hadronic showers. In this, the clustering algorithm implicitly performs a topological noise suppression by removing cells with insignificant signals which are not in close proximity to cells with significant signals.
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