Publications by authors named "Thomas Pin"

Thanks to recent progress in cancer research, most children treated for cancer survive into adulthood. Nevertheless, the long-term consequences of anticancer agents are understudied, especially in the pediatric population. We and others have shown that routinely administered chemotherapeutics drive musculoskeletal alterations, which contribute to increased treatment-related toxicity and long-term morbidity.

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  • - Primary ciliary dyskinesia (PCD) is a rare condition linked to dysfunctional cilia, primarily affecting males, but the study investigates the effects of X chromosome inactivation (XCI) in their healthy mothers who carry the mutation.
  • - The analysis of six mothers revealed varying degrees of respiratory symptoms that correlated with their XCI patterns and the presence of normal ciliated cells in their airways.
  • - The findings suggest that identifying female carriers of PCD mutations is essential, especially if they have mild respiratory issues, and highlight that having a sufficient proportion of normal ciliated cells can prevent severe symptoms, indicating potential for gene therapy.
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  • The Concise Guide to PHARMACOLOGY 2023/24 offers a summarized overview of approximately 1800 drug targets and around 6000 interactions with 3900 ligands, mostly in a tabular format.
  • It focuses on selective pharmacology and includes links to an open access knowledgebase for more detailed drug information.
  • The guide divides drug targets into six major categories, providing essential summaries and guidance based on the latest pharmacological data available as of mid-2023, while serving as an official resource by the International Union of Basic and Clinical Pharmacology.
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Introduction: Thrombotic events in neonates and children represent a rare although severe occurrence in view of the associated risk of mortality and sequelae. Quality evidence is limited in this field, and registry studies provide an essential base for research. The aim of this paper is to present the new Italian Registry of Infantile Thrombosis (RITI), set it into the scene of international thrombosis and stroke registries, and provide some insight on the challenges associated with registry management.

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  • The study explores the unknown factors driving severe COVID-19 by examining a young patient cohort without major comorbidities, comparing critical and non-critical cases.
  • Researchers used advanced techniques like whole-genome sequencing and artificial intelligence to analyze biological samples and found significant inflammatory responses and immune system alterations in critical patients.
  • A specific gene signature was identified that distinguished critical cases and indicated that inhibiting the ADAM9 gene could reduce SARS-CoV-2 infection and replication, suggesting potential therapeutic options.
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  • The Concise Guide to Pharmacology 2021/22 offers a streamlined overview of nearly 1900 human drug targets, focusing on selective pharmacology and organized mainly in tables for quick reference.
  • The guide serves as a reliable, citable resource that distills extensive online content while ensuring it reflects the status as of mid-2021, distinct from ongoing database updates.
  • Key pharmacological targets include G protein-coupled receptors, ion channels, and enzymes, with official nomenclature and references provided to assist further research and understanding.
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  • This study investigates the role of a substance called interleukin-22 (IL22) in a disease called chronic colitis, which affects the colon.
  • Researchers used special lab techniques and models to see how IL22 impacts the cells in the colon.
  • The results showed that IL22 might not be as helpful as previously thought and instead could make the disease worse, suggesting new ways to treat colitis by focusing on IL22 and related stress in the colon.
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The glutamate metabotropic receptor 4 () locus is linked to susceptibility to human osteosarcoma, through unknown mechanisms. We show that gene-targeted mice demonstrate accelerated radiation-induced tumor development to an extent comparable with mice. GRM4 is expressed in myeloid cells, selectively regulating expression of IL23 and the related cytokine IL12.

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A measurement of the mass of the boson is presented based on proton-proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to of integrated luminosity. The selected data sample consists of candidates in the channel and candidates in the channel. The -boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the boson transverse mass in the electron and muon decay channels, yielding where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty.

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The modification of the production of , , and ( ) in +Pb collisions with respect to their production in collisions has been studied. The +Pb and datasets used in this paper correspond to integrated luminosities of and respectively, collected in 2013 and 2015 by the ATLAS detector at the LHC, both at a centre-of-mass energy per nucleon pair of 5.02 TeV.

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A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of collisions corresponding to an integrated luminosity of 36.1 fb , recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV.

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The results of a search for new heavy bosons decaying to an electron or muon and a neutrino using proton-proton collision data at a centre-of-mass energy of  TeV are presented. The dataset was collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 36.1  .

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  • The analysis involves searching for massive colored resonances that decay into two jets using data from the ATLAS experiment at the LHC, collected in 2015 and 2016.
  • No significant anomalies were found compared to background predictions, leading to the exclusion of certain mass ranges for the lightest supersymmetric particle, which is identified as the top squark.
  • Results indicate that top squarks with specified mass ranges are excluded at a 95% confidence level, and additional limits on colored octet resonances are also established.
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The performance of the missing transverse momentum ( ) reconstruction with the ATLAS detector is evaluated using data collected in proton-proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015. To reconstruct , fully calibrated electrons, muons, photons, hadronically decaying , and jets reconstructed from calorimeter energy deposits and charged-particle tracks are used. These are combined with the soft hadronic activity measured by reconstructed charged-particle tracks not associated with the hard objects.

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A search for the electroweak production of charginos, neutralinos and sleptons decaying into final states involving two or three electrons or muons is presented. The analysis is based on 36.1 fb of  TeV proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider.

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Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb[over ¯] pair with the ATLAS detector using 36.1  fb^{-1} of pp collisions at a center-of-mass energy of 13 TeV at the LHC.

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A search for heavy pseudoscalar (A) and scalar (H) Higgs bosons decaying into a top quark pair (tt[over ¯]) has been performed with 20.3  fb^{-1} of proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a center-of-mass energy sqrt[s]=8  TeV. Interference effects between the signal process and standard model tt[over ¯] production, which are expected to distort the signal shape from a single peak to a peak-dip structure, are taken into account.

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Multi-particle cumulants and corresponding Fourier harmonics are measured for azimuthal angle distributions of charged particles in [Formula: see text] collisions at [Formula: see text] = 5.02 and 13 TeV and in [Formula: see text] + Pb collisions at [Formula: see text] = 5.02 TeV, and compared to the results obtained for low-multiplicity [Formula: see text] collisions at [Formula: see text] = 2.

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Measurements of the production cross section of a [Formula: see text] boson in association with jets in proton-proton collisions at [Formula: see text] TeV are presented, using data corresponding to an integrated luminosity of 3.16 fb[Formula: see text] collected by the ATLAS experiment at the CERN Large Hadron Collider in 2015. Inclusive and differential cross sections are measured for events containing a [Formula: see text] boson decaying to electrons or muons and produced in association with up to seven jets with [Formula: see text] GeV and [Formula: see text].

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With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 [Formula: see text] for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.

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A search for the dimuon decay of the Higgs boson was performed using data corresponding to an integrated luminosity of 36.1  fb^{-1} collected with the ATLAS detector in pp collisions at sqrt[s]=13  TeV at the Large Hadron Collider. No significant excess is observed above the expected background.

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Detailed measurements of -channel single top-quark production are presented. They use 20.2 fb[Formula: see text] of data collected by the ATLAS experiment in proton-proton collisions at a centre-of-mass energy of 8 TeV at the LHC.

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The reconstruction of the signal from hadrons and jets emerging from the proton-proton collisions at the Large Hadron Collider (LHC) and entering the ATLAS calorimeters is based on a three-dimensional topological clustering of individual calorimeter cell signals. The cluster formation follows cell signal-significance patterns generated by electromagnetic and hadronic showers. In this, the clustering algorithm implicitly performs a topological noise suppression by removing cells with insignificant signals which are not in close proximity to cells with significant signals.

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