Publications by authors named "Thomas Patrick Ahern"
Phthalate exposure from drugs during pregnancy and possible risk of preterm birth and small for gestational age.
Eur J Obstet Gynecol Reprod Biol
September 2019
Background: Phthalates are chemical compounds present in a wide range of consumer products and are thought to be endocrine disruptors. Though not commonly known, phthalates are present in some medication with previous studies finding up to 50-fold higher urinary metabolite concentrations among exposed compared to the general population. Previous studies on environmental phthalate exposure and pregnancy outcomes have been contradictory and inconclusive and all previous studies have assessed phthalate exposure using biomarkers despite a known rapid metabolism of phthalates.
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- Phthalates, commonly found in some medications, have been linked to increased urinary excretion in users and potential stimulation of gastric cancer mechanisms.
- A study analyzed data from the Danish Cancer Registry from 2008 to 2015, examining the link between cumulative phthalate exposure from drug products and gastric adenocarcinomas in patients.
- Despite high exposure levels to various phthalates, the study found no significant association with the risk of developing gastric adenocarcinomas, though it noted limitations due to the low number of cases with high exposure.
Purpose: Some drug products contain phthalates as excipients, and in vitro studies have demonstrated that phthalates interfere with cellular mechanisms involved in colorectal cancer development. We therefore examined the association between cumulative phthalate exposure from drug products and risk of colorectal adenocarcinomas.
Methods: We used the Danish Cancer Registry to identify all patients with incident colorectal adenocarcinoma from 2008 to 2015 (n = 25 814).