Task-Driven Neurophysiological qEEG Baseline Performance Capabilities in Healthy, Uninjured Division-I College Athletes.

Background: Athletic performance can be measured with a variety of clinical and functional assessment techniques. There is a need to better understand the relationship between the brain's electrical activity and the body's physiological performance capabilities in real-time while performing physical tasks related to sport. Orthopedic functional assessments used to monitor the neuroplastic properties of the central nervous system lack objectivity and/or pertinent functionality specific to sport.

The Effect of a Novel Weight-Supported Kinetic Chain Resistance Training Program on Proximal Core Muscular Endurance, Trunk-to-Arm Muscular Power, and Bat Swing Speed.

Palmer, TG, and McCabe, M. The effect of a novel weight-supported kinetic chain resistance training program on proximal core muscular endurance, trunk-to-arm muscular power, and bat swing speed. J Strength Cond Res 37(11): 2130-2140, 2023-Muscular stability and muscular power at the proximal core segments of the pelvis, spine, and trunk are essential attributes in maximizing bat swing speed in the sport of softball.

The Longitudinal Neurophysiological Adaptation of a Division I Female Lacrosse Player Following Anterior Cruciate Rupture and Repair: A Case Report.

Background: Neurophysiological adaptation following anterior cruciate ligament (ACL) rupture and repair (ACLR) is critical in establishing neural pathways during the rehabilitation process. However, there is limited objective measures available to assess neurological and physiological markers of rehabilitation.

Purpose: To investigate the innovative use of quantitative electroencephalography (qEEG) to monitor the longitudinal change in brain and central nervous systems activity while measuring musculoskeletal function during an anterior cruciate ligament repair rehabilitation.

Caudal-Rostral Progression of Alpha Motoneuron Degeneration in the SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.

Mice with transgenic expression of human SOD1 are a widely used model of ALS, with a caudal-rostral progression of motor impairment. Previous studies have quantified the progression of motoneuron (MN) degeneration based on size, even though alpha (α-) and gamma (γ-) MNs overlap in size. Therefore, using molecular markers and synaptic inputs, we quantified the survival of α-MNs and γ-MNs at the lumbar and cervical spinal segments of 3- and 4-month SOD1 mice, to investigate whether there is a caudal-rostral progression of MN death.

Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of in SMA Type I Fibroblasts.

Spinal muscular atrophy (SMA) is a severe, debilitating neuromuscular condition characterised by loss of motor neurons and progressive muscle wasting. SMA is caused by a loss of expression of that encodes the survival motor neuron (SMN) protein necessary for the survival of motor neurons. Restoration of SMN expression through increased inclusion of exon 7 is known to ameliorate symptoms in SMA patients.

Systematic Literature Review of Real-world Evidence of Ceftolozane/Tazobactam for the Treatment of Respiratory Infections.

Introduction: Gram-negative nosocomial pneumonia (NP), including hospital-acquired bacterial pneumonia (HABP), ventilated HABP (vHABP), and ventilator-associated bacterial pneumonia (VABP), is a significant cause of morbidity and mortality. Common pathogens, including Enterobacterales and Pseudomonas aeruginosa, are prevalent in healthcare settings and have few effective treatment options due to high rates of antibacterial resistance. Resistant pathogens are associated with significantly worse outcomes, relative to patients with susceptible infections.

Physiological Monitoring Detected Changes During Women's Soccer Anterior Cruciate Ligament Injury.

A growing number of studies utilizing wearable technologies are examining the influence of the autonomic nervous system (ANS) on intense training, recovery, and injury risk. Exercise biometric (EB) data were collected on collegiate, female soccer players during a preseason camp. One player sustained an anterior cruciate ligament (ACL) injury.

Real-world use of ceftolozane/tazobactam: a systematic literature review.

Background: Antibacterial-resistant gram-negative infections are a serious risk to global public health. Resistant Enterobacterales and Pseudomonas aeruginosa are highly prevalent, particularly in healthcare settings, and there are limited effective treatment options. Patients with infections caused by resistant pathogens have considerably worse outcomes, and incur significantly higher costs, relative to patients with susceptible infections.

Exacerbation Patterns in Adults with Asthma in England. A Population-based Study.

Rationale: Asthma is heterogeneous and knowledge on exacerbation patterns is lacking. Previous studies have had a relatively short follow-up or focused on severe disease.

Objectives: To describe exacerbation patterns over a prolonged follow-up in a population that includes patients of all disease severity.

The Economic Burden of Pediatric Asthma in the United States: Literature Review of Current Evidence.

Asthma is a chronic respiratory disease that is widespread throughout the US population and disproportionately affects children. This literature review aimed to identify recent information regarding the economic burden of pediatric asthma in the US. MEDLINE, EMBASE, Econlit, and PsycINFO databases and gray literature sources were searched from January 2012 to January 2018 to capture relevant publications.

Effects of Pulmonary Rehabilitation on Exacerbation Number and Severity in People With COPD: An Historical Cohort Study Using Electronic Health Records.

Background: In previous systematic reviews (predominantly of randomized controlled trials), pulmonary rehabilitation (PR) has been shown to reduce hospital admissions for acute exacerbations of COPD (AECOPD). However, findings have been less consistent for cohort studies. The goal of this study was to compare rates of hospitalized and general practice (GP)-treated AECOPD prior to and following PR.

Thermodynamic formalism for transport coefficients with an application to the shear modulus and shear viscosity.

We discuss Onsager's thermodynamic formalism for transport coefficients and apply it to the calculation of the shear modulus and shear viscosity of a monodisperse system of repulsive particles. We focus on the concept of extensive "distance" and intensive "field" conjugated via a Fenchel-Legendre transform involving a thermodynamic(-like) potential, which allows to switch ensembles. Employing Brownian dynamics, we calculate both the shear modulus and the shear viscosity from strain fluctuations and show that they agree with direct calculations from strained and non-equilibrium simulations, respectively.

Antipsychotic prescribing in care homes before and after launch of a national dementia strategy: an observational study in English institutions over a 4-year period.

Objectives: To assess associations between the launch of the National Dementia Strategy (NDS) and antipsychotic prescribing in long-term residential care (LTC) in England.

Setting And Participants: Retrospective analysis of prescribing patterns in 616 LTC institutions (31 619 residents) following launch of the NDS, using information from electronic medicines management system.

Primary And Secondary Outcome Measures: Antipsychotic prescribing point prevalence (PP) for all residents in a cross section of LTC settings over a 4-year period following NDS launch.

Pulmonary Rehabilitation as a Mechanism to Reduce Hospitalizations for Acute Exacerbations of COPD: A Systematic Review and Meta-Analysis.

Background: Acute exacerbation of COPD (AECOPD) has a significant impact on health-care use, including physician visits and hospitalizations. Previous studies and reviews have shown that pulmonary rehabilitation (PR) has many benefits, but the effect on hospitalizations for AECOPD is inconclusive.

Methods: A literature search was carried out to find studies that might help determine, using a meta-analysis, the impact of PR on AECOPD, defined as unscheduled or emergency hospitalizations and ED visits.

Obstructive Jaundice from Metastatic Squamous Cell Carcinoma of the Lung.

Obstructive jaundice from metastatic lung cancer is extremely rare. Most reported cases have had small cell cancer of lung or adenocarcinoma of lung as primary malignancy metastasizing to the biliary system. We report the case of a patient presenting with symptoms of obstructive jaundice found to have metastatic involvement of hepatobiliary system from squamous cell cancer (SCC) of lung.

Relationship of Physical Fitness Measures vs. Occupational Physical Ability in Campus Law Enforcement Officers.

Law enforcement officers (LEOs) on university campuses are required to perform a variety of physical occupational tasks. Identifying which physical fitness characteristics are associated with these occupational tasks will assist in the development of appropriate exercise programs and physical fitness assessments. Therefore, the purpose of this study was to identify physical fitness and demographic characteristics that were correlated with occupational tasks commonly performed by campus LEOs.

Sport-Specific Training Targeting the Proximal Segments and Throwing Velocity in Collegiate Throwing Athletes.

Context: The ability to generate, absorb, and transmit forces through the proximal segments of the pelvis, spine, and trunk has been proposed to influence sport performance, yet traditional training techniques targeting the proximal segments have had limited success improving sport-specific performance.

Objective: To investigate the effects of a traditional endurance-training program and a sport-specific power-training program targeting the muscles that support the proximal segments and throwing velocity.

Design: Randomized controlled clinical trial.

The effect of a novel tactical training program on physical fitness and occupational performance in firefighters.

Structural firefighting is a dangerous and physically demanding profession. Thus, it is critical that firefighters exercise regularly to maintain optimal physical fitness levels. However, little is known about optimal training methods for firefighters, and exercise equipment is often not available to on-duty firefighters.

Comparison of isokinetic hip abduction and adduction peak torques and ratio between sexes.

Objective: To evaluate hip abductor and adductor peak torque outputs and compare their ratios between sexes.

Design: A cross-sectional laboratory-controlled study.

Setting: Participants visited a laboratory and performed an isokinetic hip abductor and adductor test.

Best evidence topic reports. BET 1: Ambulatory care in well adults diagnosed with malaria in the emergency department.

A short-cut review was carried out to establish whether patients with malaria can be safely treated as outpatients. Thirty-six papers were found, of which four presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated.

Soccer-specific warm-up and lower extremity injury rates in collegiate male soccer players.

Context: A number of comprehensive injury-prevention programs have demonstrated injury risk-reduction effects but have had limited adoption across athletic settings. This may be due to program noncompliance, minimal exercise supervision, lack of exercise progression, and sport specificity. A soccer-specific program described as the F-MARC 11+ was developed by an expert group in association with the Federation Internationale de Football Association (FIFA) Medical Assessment and Research Centre (F-MARC) to require minimal equipment and implementation as part of regular soccer training.