Publications by authors named "Thomas P Mullins"
The measurement of glomerular filtration rate (GFR) is essential to understanding renal physiology, including the monitoring of disease progression and treatment effectiveness. Transdermal measurement of glomerular filtration rate (tGFR) using a miniaturized fluorescence monitor in combination with a fluorescent exogenous GFR tracer has become a common technique to measure GFR in the preclinical setting, especially in rodent models. It allows for close to real-time measurement of GFR in conscious unrestrained animals and overcomes several limitations of other GFR measures.
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- Selective SGLT2 inhibition can lower the risk of worsening heart failure and cardiovascular death, regardless of whether patients have diabetes.
- This study explored the impact of dual SGLT1/2 inhibition using sotagliflozin on heart conditions in normal diet and high-fat diet mice experiencing cardiac pressure overload.
- Results showed that sotagliflozin improved cardiac health in normal diet mice but had limited effectiveness in high-fat diet mice due to impaired kidney function and lower drug response.
Background And Aims: Previous literature have shown a diversity of findings regarding the relationship between the maternal gut microbiota and gestational diabetes mellitus (GDM). We investigated the gut microbiota of overweight and obese women with gestational diabetes mellitus (GDM) against matched euglycaemic women at 16 and 28-weeks' gestation.
Methods And Results: This study included women from the SPRING (Study of PRobiotics IN Gestational diabetes) cohort.
Aim: The measurement of glomerular filtration rate (GFR) in experimental rodents is pivotal to understanding the progression of kidney disease and benefits of treatment strategies. A non-invasive clearance device has been developed, which measures transcutaneous decay of injected FITC-sinistrin in conscious rodents. The technique was validated against the well-established plasma clearance method in the same mice, but on consecutive days, using only models of uninephrectomy and polycystic kidney disease.
View Article and Find Full Text PDFThere is an increased incidence of heart failure in individuals with diabetes mellitus (DM). The coexistence of kidney disease in DM exacerbates the cardiovascular prognosis. Researchers have attempted to combine the critical features of heart failure, using transverse aortic constriction, with DM in mice, but variable findings have been reported.
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