Publications by authors named "Thomas P I Pembroke"
Article Synopsis
- The study analyzes trends in liver disease incidence in Wales from 1999 to 2019, finding a significant rise in cases affecting hepatology services.
- The increase in liver diseases is predominantly due to a tenfold rise in non-alcoholic fatty liver disease (NAFLD), which became the leading cause since 2014.
- While liver-related mortality doubled overall, alcohol-related liver disease remains serious, showing the highest rates of complications and mortality.
Natural killer (NK) cells provide an immediate first line of defence against viral infections. Memory responses, maintained by CD4(+) T cells, require exposure to viral antigen and provide long-term protection against future infections. It is known that NK cells can promote the development of the adaptive response through cytokine production and cross-talk with antigen-presenting cells.
View Article and Find Full Text PDFPsychological distress and chronic obstructive pulmonary disease in the Renfrew and Paisley (MIDSPAN) study.
J Epidemiol Community Health
September 2006
Background: This study examined whether psychological distress might be a predictor of chronic obstructive pulmonary disease (COPD).
Method: The relation between psychological distress at baseline, measured by the general health questionnaire (GHQ), and chronic bronchitis three years later, as measured by the Medical Research Council (MRC) bronchitis questionnaire and forced expiratory flow in one second (FEV(1)), was examined in 1682 men and 2203 women from the Renfrew and Paisley (MIDSPAN) study. The analyses were run on men and women separately and adjustments were made for age, socioeconomic position, and lung function at baseline (FEV(1)).