Lobar Dementia due to Extreme Widening of Virchow-Robin Spaces in One Hemisphere.

Widened perivascular spaces known as Virchow-Robin spaces (VRS) are often seen on MRI and are usually incidental findings. It is unclear if enlarged VRS can be associated with neurological deficits. In this report, we describe a case of lobar dementia associated with unusual VRS widening in one cerebral hemisphere.

CSF-tau and CSF-Abeta(1-42) in posterior cortical atrophy.

Objective: Our purpose was to measure Abeta(1-42), T-tau and P-tau(181) in the cerebrospinal fluid (CSF) of patients with posterior cortical atrophy (PCA), a presenile dementia likely to represent a variant of Alzheimer's disease (AD).

Methods: CSF samples from 34 subjects including 9 patients with PCA, 11 age-matched patients with AD and 14 age-matched cognitively healthy controls were analyzed using commercially available ELISA kits.

Results: The Abeta(1-42), T-tau and P-tau(181) levels in PCA patients differed significantly (p < 0.

Clinical characteristics of dementia associated with argyrophilic grain disease.

Background/aims: We aimed at characterizing the clinical features of dementia associated with argyrophilic grain disease (AgD).

Methods: Relatives or close friends of 24 individuals with autopsy-confirmed AgD and 29 patients with autopsy-confirmed Alzheimer's disease (AD) were administered a novel Retrospective Dementia Inventory to assess the cognitive, behavioral and affective symptoms of the deceased patients.

Results: AgD patients showed less severe impairments in memory, language, attention and executive function than AD patients.