Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation.

Several anesthetics have been reported to suppress the transcription of a number of genes, including Arc, also known as Arg3.1, an immediate early gene that plays a significant role in memory consolidation. The purpose of this study was to explore the mechanism of anesthesia-mediated depression in Arc gene and protein expression.