Clopidogrel resistance is common in patients undergoing vascular and coronary interventions.

Objectives: "Clopidogrel resistance," also defined as heightened platelet reactivity (HPR) while on clopidogrel therapy, may lead to a sub-optimal antiplatelet effect and a potential thrombotic event. There is limited literature addressing the prevalence of HPR in a large cohort of patients receiving either coronary or endovascular interventions.

Methods: In a large integrated healthcare system, patients with a P2Y12 reaction units (PRU) test were identified.

Rapid progression of carotid stenosis was rare in a large integrated healthcare system during an eight-year period.

Objective: Few studies have evaluated the rapid progression of carotid stenosis on a large scale. We created a custom software algorithm to analyze an electronic medical record database to examine the natural progression of carotid stenosis, identify a subset of patients with rapid progression, and evaluate the specific patient risk factors associated with this rapid progression.

Methods: Patients in a large integrated healthcare system who had undergone two or more carotid ultrasound scans from August 2010 to August 2018 were identified.