Publications by authors named "Thomas Martin Doring"
Dysregulation of brain iron homeostasis is a hallmark of many neurodegenerative diseases and can be associated with oxidative stress. The objective of this study was to investigate brain iron in patients with Neuromyelitis Optica (NMO) using quantitative susceptibility mapping (QSM), a quantitative iron-sensitive MRI technique. 12 clinically confirmed NMO patients (6 female and 6 male; age 35.
View Article and Find Full Text PDFBackground And Purpose: In patients with neuromyelitis optica (NMO), damage to extensive regions of normal-appearing WM has been observed. To investigate the possibility that microstructural alterations are present in these WM tracts, DTI and diffusion kurtosis imaging (DKI) techniques were applied and compared.
Material And Methods: Thirteen patients with NMO and 13 demographically and gender-matched controls underwent MRI using a 3T MR scanner, with DTI/DKI sequence acquired jointly fitted.
Background: Chronic pain disorders are presumed to induce changes in brain grey and white matters. Few studies have focused CNS alterations in trigeminal neuralgia (TN).
Methods: The aim of this study was to explore changes in white matter microstructure in TN subjects using diffusion tensor images (DTI) with tract-based spatial statistics (TBSS); and cortical thickness changes with surface based morphometry.
Article Synopsis
- - The article discusses advanced magnetic resonance imaging (MRI) techniques focused on assessing white matter diseases, including magnetization transfer and diffusion tensor imaging.
- - Key methods like proton magnetic resonance spectroscopy and perfusion techniques are explored to enhance understanding of white matter physiopathology.
- - These advanced imaging techniques significantly aid in differential diagnosis and inform treatment options for patients with white matter diseases.