In vivo assessment of a modification of a domiciliary ventilator which reduces oxygen consumption in mechanically ventilated patients.

There are instances where hospitals may experience a relative shortage of oxygen, for example, future pandemics, natural disasters or wartime. We developed a modification to a domiciliary ventilator that captures oxygen normally vented during expiration into the atmosphere, delivering it to the patient. The modification significantly increases PaO in mechanically ventilated patients at their baseline FiO and baseline FiO +1, +2 and +3 L/min compared to no modification.

Congenital heart defects in siblings with partial aneuploidy of chromosome 2p.

Cytogenetic anomalies are found in 13% of children with congenital heart disease, providing positional information that may aid in identifying genes governing cardiac development. We report two children born to a clinically normal female with a balanced chromosomal rearrangement, resulting from insertion of 2p24.2-p25.

Transposition of the great arteries with coexisting sinus of valsalva aneurysm.

Transposition of the great arteries, with or without ventricular septal defect, and sinus of valsalva aneurysm (SVA) are lesions with well-established surgical therapies associated with excellent early and late outcomes. They have never, however, been reported as coexisting lesions. Their occurrence together has significant implications regarding sites of origin and rupture or obstruction in light of the altered relationships of the arterial roots and the ventricular masses.