Publications by authors named "Thomas L Leung"
Sci Transl Med
November 2014
Article Synopsis
- - Patients with recessive dystrophic epidermolysis bullosa (RDEB) have issues with type VII collagen due to mutations in the COL7A1 gene, leading to severe skin problems and a risk of cancer.
- - Researchers developed a method to create corrected skin cells from these patients using induced pluripotent stem cells (iPSCs), which were successfully edited to produce functional type VII collagen.
- - The study shows that these corrected iPSC-derived keratinocytes can form healthy skin in lab tests and could potentially provide a new treatment approach for RDEB patients, minimizing the risk of cancer by selecting cells with fewer mutations.
