Publications by authors named "Thomas Kusmenkov"
Article Synopsis
- * In a study involving 49 trauma patients, a high percentage (75.5%) survived, but many (77%) experienced multiple organ failure, while initial prothrombin times indicated coagulopathy in 31 patients.
- * Plasma levels of glycocalyx components syndecan-1 and hyaluronan increased significantly in the first 12 hours post-trauma, with heightened levels correlating to organ failure and mortality.
Article Synopsis
- A study analyzed the use of CarpoFit® trapeziometacarpal prostheses in 292 patients with stage I-III arthritis who were symptomatic after non-surgical treatments from 2006 to 2014.
- Patients showed significant improvements in pain relief and functionality as early as 3 months post-surgery, with results maintained for up to 10 years.
- At a 10-year follow-up, 91% of patients reported high satisfaction and the implant had a 95% survival rate, indicating the efficacy of prosthetic arthroplasty for this condition.*
Introduction: Patients after polytrauma suffer from posttraumatic immune system dysregulation and multiple organ dysfunction. Genome-wide microarray profiling in monocytes revealed a regulatory network of inflammatory markers around the transcription factor AP-1 in severely injured patients. Recent research focuses on the role of neutrophils in posttraumatic inflammation.
View Article and Find Full Text PDFBackground: Split-depression fractures to the lateral tibial plateau (AO41B3) often feature severe joint surface destructions. Precontoured locking compression plates (LCPs) are designed for optimum support of the reduced joint surface and have especially been emphasized in reduced bone quality. A lack of evidence still inhibits their broad utilization in elderly patients.
View Article and Find Full Text PDFBackground: Patients after polytrauma regularly suffer from posttraumatic immune system destabilization, which closely influences the further clinical development. Increasing age has recently been identified as an isolated risk factor for an adverse outcome after major trauma. Higher rates and intensity of acute inflammation following severe injury suggest that deregulated inflammation may contribute to these higher rates of posttraumatic morbidity and mortality in older adults.
View Article and Find Full Text PDFBackground: A declining selenium (Se) status constitutes a characteristic of critical illness and may affect disease course and survival. The dynamics of trauma-induced changes in biomarkers of Se status are poorly characterized, and an association with multiple organ failure (MOF) and mortality can be hypothesized. It was the aim of this study to investigate Se and selenoprotein P (SELENOP) concentrations in major trauma patients during the early posttraumatic period.
View Article and Find Full Text PDFIntroduction: The purpose of this study was to evaluate immediate immunological changes following cardiopulmonary resuscitation (CPR). mRNA expression levels of selected immunomodulatory cytokines in out-of-hospital cardiac arrest (OHCA) survivors were detected and correlated to clinical parameter.
Methods: OHCA survivors with sustained unconsciousness after return of spontaneous circulation (ROSC) were included.