Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project.

This paper presents the concept of a novel adaptable sensing solution currently being developed under the EU Commission-founded PHOTONGATE project. This concept will allow for the quantification of multiple analytes of the same or different nature (chemicals, metals, bacteria, etc.) in a single test with levels of sensitivity and selectivity at/or over those offered by current solutions.

In vivo evaluation of a chip based near infrared sensor for continuous glucose monitoring.

In this paper we describe the concept and in vivo results of a minimally invasive, chip-based near infrared (NIR) sensor, combined with microdialysis, for continuous glucose monitoring. The sensor principle is based on difference absorption spectroscopy in selected wavelength bands of the near infrared spectrum (1300 nm, 1450 nm, and 1550 nm) in the 1st overtone band. In vitro measurements revealed a linear relationship between glucose concentration and the integrated difference spectroscopy signal with a coefficient of determination of 99% in the concentration range of 0-400mg/dl.

Laser-machined fibers as Fabry-Perot pressure sensors.

Cavities have been laser ablated in the ends of single-mode optical fibers and sealed by aluminized polycarbonate diaphragms to produce Fabry-Perot pressure sensors. Both conventional fibers and novel, multicore fibers were used, demonstrating the possibility of producing compact arrays of sensors and multiple sensors on an individual fiber 125 microm in diameter. This high spatial resolution can be combined with high temporal resolution by simultaneously interrogating the sensors by using separate laser sources at three wavelengths.

Miniaturization of a biomedical gas sensor.

In a previous study, we concluded that a conductivity based PCO2 sensor is an attractive solution for early detection of ischemia and presented two design geometries. For organ surface measurements, the planar design was suitable but it was difficult to insert the sensor into the tissue. A cylindrical design solution was favored for insertion due to the large membrane contact area and easy placement in a medical catheter.