Publications by authors named "Thomas Kaleta"
Article Synopsis
- The study investigates the role of androgen receptor (AR) in disseminated tumor cells (DTCs) as a potential marker for minimal residual disease (MRD) and metastasis in early breast cancer (BC) patients.
- Out of 62 patients tested, AR expression was found in 43% of DTCs, but there was only a 33% concordance between DTCs and primary tumor (PT) AR statuses.
- The findings suggest a notable discordance in AR status between DTCs and PTs, highlighting the need for further research to understand the clinical implications of AR-positive DTCs in early BC.
Intraoperative frozen section analysis (FSA) of sentinel lymph nodes (SLNs) declined in the post American College of Surgeons Oncology Group Z0011 (ACOSOG Z0011) trial era. However, for those patients who do not meet the ACOSOG Z0011 criteria, FSA continues to be a valuable tool in intraoperative decision-making for axillary lymph node dissection (ALND). The aim of this study was therefore to retrospectively evaluate the benefit and accuracy of FSA of Z0011 criteria eligible versus ineligible patients and identify possible predictive factors for false negative results.
View Article and Find Full Text PDFBackground: The question of how to deal with B3 lesions is of emerging interest.
Methods: In the breast diagnostics of 192 patients between 2009 and 2016, a minimally invasive biopsy revealed a B3 lesion with subsequent resection. This study investigates the malignancy rate of different B3 subgroups and the risk factors that play a role in obtaining a malignant finding.
Invasive breast cancer with neuroendocrine differentiation is a rare subtype of breast malignancy. Due to frequent changes in the definition of these lesions, the correct diagnosis, estimation of exact prevalence, and clinical behaviour of this entity may be challenging. The aim of this study was to evaluate the prevalence, clinical features, and outcomes in a large cohort of patients with breast cancer with neuroendocrine differentiation.
View Article and Find Full Text PDFBackground: The prognostic relevance of circulating tumour cells (CTCs) in metastatic breast cancer (MBC) patients has been confirmed by several clinical trials. However, predictive blood-based biomarkers for stratification of patients for targeted therapy are still lacking. The DETECT studies explore the utility of CTC phenotype for treatment decisions in patients with HER2 negative MBC.
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