Infectious complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions to medications characterized by keratinocyte necrosis leading to loss of protective barrier function and increased susceptibility to infection. Infection is a major cause of morbidity, and septicemia is the leading cause of mortality in this population. This systematic review and meta-analysis aimed to determine infectious complications' prevalence and risk factors in adults with SJS and TEN.

A systematic review of case-control studies of cytokines in blister fluid and skin tissue of patients with Stevens Johnson syndrome and toxic epidermal necrolysis.

Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions characterised by keratinocyte apoptosis, necroptosis and epidermal detachment. Several cytokines and cytotoxic proteins have been shown to be elevated in the blood and skin of SJS/TEN sufferers and biologics such as intravenous immune globulin and tumour necrosis factor (TNF)-alpha inhibitors have demonstrated good therapeutic potential. The exact pathogenic model of SJS/TEN however remains elusive.

Mohs Micrographic Surgery in Patients Younger Than 40 Years.

Background: As the availability of Mohs micrographic surgery (MMS) continues to expand in Australia and incidence of keratinocyte cancer increases in adolescents and young adults, there has been rising interest in the use of MMS in this population.

Objective: This study aimed to evaluate the characteristics of MMS cases in patients younger than 40 years.

Methods: A review was performed of all MMS cases in patients younger than 40 years at the time of their surgery from 2012 to 2017 at the Skin and Cancer Foundation Australia, with comparison to a control group, aged older than 40 years.

Case-controlled study of skin conditions in HIV-negative men who have sex with men.

Most of the dermatological research in men who have sex with men (MSM) has been in the HIV-infected subpopulation. A retrospective case-control study was performed of dermatologic diagnoses in HIV-negative MSM (n = 329) compared with male heterosexual controls (n = 600). HIV-negative MSM had a higher frequency of folliculitis (19/329 vs 12/600; P = 0.

Mohs Micrographic Surgery at the Skin and Cancer Foundation Australia, 20 Years Later (1997-2017).

Background: The availability of Mohs micrographic surgery (MMS) in Australia has increased dramatically since its inception in the 1980s.

Objective: This study aimed to describe the evolution of MMS practices at the Skin and Cancer Foundation Australia (SCFA) over the past 20 years (1997-2017).

Methods: Retrospective analysis of Mohs surgery cases at SCFA in 2017, 2007, and 1997, comparing data on sex, age, tumor type and site, initial tumor and final defect size, number of surgical stages and sections, and closure management.

Hormonal and dietary factors in acne vulgaris versus controls.

: Acne vulgaris is an inflammatory skin disorder with not as yet fully understood pathogenesis. In this controlled study, we assessed acne vulgaris patients for several possible pathogenic factors such as vitamin D deficiency, vegan diet, increased body mass index (BMI) and positive anti-transglutaminase antibody. : We screened 10 years of records at a family medicine clinic for patients diagnosed with acne vulgaris.

The associations between psychological stress and psoriasis: a systematic review.

Psoriasis is estimated to affect around 2-3% of the general population. More than one-third of Australians report having a significant level of distress in their daily lives. Psychological stress has long been shown to play an important role in the natural history of psoriasis, but the details of this relationship remain to be clearly defined.

Risk factors for positive margins after wide local excision of cutaneous squamous cell carcinoma.

Background And Objectives: The standard treatment for cutaneous squamous cell carcinoma (cSCC) is wide local excision (WLE). Incomplete tumor excision is associated with increased recurrence rates and mortality risk. Risk factors for positive margins after WLE of cSCC has been examined in only a few studies.

Overwintering Survival of Drosophila suzukii (Diptera: Drosophilidae) and the Effect of Food on Adult Survival in California's San Joaquin Valley.

The overwintering survival and development of Drosophila suzukii Matsumura were investigated in California's San Joaquin Valley. Drosophila suzukii were exposed to overwintering conditions in cages hung in a citrus orchard, and the pupae were buried in the soil. Eggs exposed from late November to January did not survive; a low percentage (<3%) of larvae and pupae developed into adults.

Factors Limiting Peach as a Potential Host for Drosophila suzukii (Diptera: Drosophilidae).

The spotted wing drosophila, Drosophila suzukii Matsumura, has widely established in North America and become an economic concern for a variety of fruit crops. To better understand fruit susceptibility, we evaluated peach surface characteristics on the pest's oviposition success. The number of D.