A comparison of two treatment regimens of ceftriaxone in late Lyme disease.

Background: The optimal duration of treatment for patients with late Lyme disease is unresolved.

Methods: In a prospective, open label, randomized, multi-center study, a 14 day course of ceftriaxone was compared to 28 days of therapy. Entry criteria included objective abnormalities compatible with late Lyme disease and serologic reactivity to Borrelia burgdorferi.