A role for SPARC in the moderation of human insulin secretion.

Aims/hypothesis: We have previously shown the implication of the multifunctional protein SPARC (Secreted protein acidic and rich in cysteine)/osteonectin in insulin resistance but potential effects on beta-cell function have not been assessed. We therefore aimed to characterise the effect of SPARC on beta-cell function and features of diabetes.

Methods: We measured SPARC expression by qRT-PCR in human primary pancreatic islets, adipose tissue, liver and muscle.