Circadian rhythms differ between young adult males and females. For example, males tend to be later chronotypes, preferring later timing of sleep and activity, than females. Likewise, there are sex differences in body composition and cardiorespiratory fitness.
View Article and Find Full Text PDFBackground: Cardiorespiratory fitness, typically measured as peak oxygen uptake (VO) during maximal graded exercise testing (GXT), is a predictor of morbidity, mortality, and cardiovascular disease. However, measuring VO is costly and inconvenient and thus not widely used in clinical settings. Alternatively, postexercise heart rate recovery (HRRec), which is an index of vagal reactivation, is a valuable assessment of VO in older adults and athletes.
View Article and Find Full Text PDFDeath receptor 5 (DR5) is an attractive target for cancer therapy due to its broad upregulated expression in multiple cancers and ability to directly induce apoptosis. Though anti-DR5 IgG antibodies have been evaluated in clinical trials, limited efficacy has been attributed to insufficient receptor crosslinking. IGM-8444 is an engineered, multivalent agonistic IgM antibody with 10 binding sites to DR5 that induces cancer cell apoptosis through efficient DR5 multimerization.
View Article and Find Full Text PDFBACKGROUNDThe circadian system entrains behavioral and physiological rhythms to environmental cycles, and modern lifestyles disrupt this entrainment. We investigated a timed exercise intervention to phase shift the internal circadian rhythm.METHODSIn 52 young, sedentary adults, dim light melatonin onset (DLMO) was measured before and after 5 days of morning (10 hours after DLMO; n = 26) or evening (20 hours after DLMO; n = 26) exercise.
View Article and Find Full Text PDFThe effects of acoustic wave propagation on the transport of colloids in saturated porous media were investigated by injecting Uranine (conservative tracer) as well as blue and red polystyrene microspheres (colloids of different diameters; 0.10 and 0.028 mum, respectively) into a column packed with glass beads.
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