Publications by authors named "Thomas J Humphries"
Article Synopsis
- The study aimed to assess the long-term prevalence and risk factors of depression symptoms in individuals 10 years after a traumatic brain injury (TBI), comparing it with rates found at 10 weeks and 1 year post-injury.
- Out of 1130 TBI patients initially recruited, follow-up at 10 years showed a decrease in depression prevalence from 56.3% at 10 weeks to 38.4%, though individual scores varied widely.
- Key risk factors for long-term depression included lower Glasgow Coma Scale (GCS) scores, social deprivation, being female, having a history of psychiatric issues, alcohol use, and unemployment, while factors like age and ethnicity had no
Article Synopsis
- Intracranial meningiomas involving bones and primary intraosseous meningiomas are rare, with no clear guidelines for treatment; this study reviews strategies and outcomes over a decade.
- A retrospective analysis of 33 adult patients reveals that most had secondary bone involvement, with many undergoing cranioplasty using various materials like polymethyl methacrylate and titanium mesh, showing a high success rate.
- The findings suggest that while different cranioplasty materials were effective, those that are pre-fabricated may lead to fewer complications, indicating the need for further research in this area.
Article Synopsis
- This study analyzed outcomes of first alloplastic cranioplasty in 287 patients, focusing on post-surgery complications and factors influencing the need for explantation, which is the removal of the implanted material.* -
- Most patients were around 43 years old, with traumatic brain injury being the leading reason for prior craniectomy; various materials, such as titanium and hydroxyapatite, were used for the cranioplasty.* -
- Results showed a 12.2% rate of all-cause explantation, with certain materials like hydroxyapatite and acrylic significantly lowering the risk of complications, while age and certain conditions increased the risk.*
Objectives: To identify risk factors for poor outcome one year post-mild traumatic brain injury (mTBI).
Design: This study was a prospective observational study using consecutive adult hospital admissions with mTBI.
Subjects: A total of 869 consecutive mTBI patients were enrolled in this study.
Objectives: Pain is a known complication in persons with hemophilia (PWH) as a result of muscle and joint bleeding. Little is known regarding national Hemophilia Treatment Center (HTC) practice patterns related to pain management. The aim of this study was to: 1) Describe pain management practice patterns of HTC providers, 2) Identify gaps and areas of alignment with the CDC pain guidelines, and 3) Address educational opportunities for pain management.
View Article and Find Full Text PDFObjective: To determine the prevalence of employment status (ES) or full-time study after traumatic brain injury (TBI) in a representative population and its predictive factors.
Design: Prospective cohort study.
Setting: Regional Major Trauma Centre.
: To assess the impact of social deprivation on Traumatic Brain Injury (TBI) global outcome.: The study was a prospective observational study conducted using consecutive admissions with TBI.: 1322 consecutive adult patients with TBI were recruited into the study between 2010 and 2015.
View Article and Find Full Text PDFCerebral microbleeds: hearing through the silence-a narrative review.
Curr Med Res Opin
February 2019
Objective: The term cerebral microbleed (CMB) refers to lesions documented as unexpected findings during computed tomography or magnetic resonance imaging examination of the brain. Initially, a CMB was thought to represent hemosiderin-laden macrophages marking an area of a tiny hemorrhage. Recently, histopathologic studies have shown that the structure of a CMB can be variable.
View Article and Find Full Text PDFPurpose: Previous retrospective claims database analyses reported increased prevalence and earlier onset of cardiovascular comorbidities in patients with versus without hemophilia A. A comprehensive chart review was designed to further investigate previous findings.
Methods: This retrospective chart review study was conducted at Henry Ford Health System (Detroit, MI, USA).
In patients with severe hemophilia A, recurrent bleeding into joints results in increased morbidity and reduced quality of life. Prophylaxis using replacement factor products, especially when initiated early, has established benefits in terms of reducing joint bleeds and preserving joint function. Poor adherence to prophylactic regimens is a common cause for breakthrough bleeds and resultant arthropathy.
View Article and Find Full Text PDFObjectives. Prophylaxis regimens for severe hemophilia A allowing more flexible dosing while maintaining efficacy may improve adherence and decrease the cost of prophylaxis. Here, we compared the clinical effectiveness of once- or twice-weekly versus ≥3-times-weekly prophylaxis with sucrose-formulated recombinant factor VIII (rFVIII-FS) in a "real-world" practice setting.
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