Publications by authors named "Thomas Inge"
Background: Metabolic and bariatric surgery is a safe and effective treatment strategy for severe childhood obesity, affecting 10% of US adolescents.
Objectives: This prospective observational study addresses knowledge gaps related to changes in weight, cardiometabolic risk, and weight-related quality of life (WRQOL) in adolescents 10 years after laparoscopic adjustable gastric band (LAGB) insertion.
Setting: Five Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) US centers.
Objective: To identify factors associated with incident alcohol consumption, hazardous drinking, alcohol-related problems, and substance use up to 8 years following metabolic and bariatric surgery (MBS) during adolescence.
Background: In this cohort, nearly half of those who underwent MBS as adolescents screened positive for alcohol use disorder, symptoms of alcohol-related harm, or alcohol-related problems within 8 years post-surgery. Moreover, persistent or heavy marijuana use following MBS during adolescence is higher than national data.
Article Synopsis
- The study investigates the link between per- and polyfluoroalkyl substances (PFAS), specifically perfluoroheptanoic acid (PFHpA), and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in obese adolescents.
- Results show that higher PFHpA plasma concentrations correlate with increased MASLD risk and that PFHpA disrupts liver metabolism, particularly lipid metabolism.
- The research also introduces a novel approach to identify individuals at high risk for PFHpA-induced MASLD and suggests potential early intervention strategies based on molecular signatures.
Article Synopsis
- PFAS are synthetic chemicals that persist in the environment and can negatively impact human health, and microRNAs can serve as biomarkers for understanding their effects.
- This study aimed to explore the relationship between PFAS levels and miRNA alterations in children using data from two cohorts in the U.S. and Greece.
- Findings showed that PFAS exposure was linked to changes in numerous miRNAs, particularly decreased levels of miR-148b-3p and miR-29a-3p, which may be associated with chronic diseases like cardiovascular issues and cancer.
Exposure to per- and poly-fluoroalkyl substances (PFAS) is ubiquitous due to their persistence in the environment and in humans. Extreme weight loss has been shown to influence concentrations of circulating persistent organic pollutants (POPs). Using data from the multi-center perspective Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort, we investigated changes in plasma-PFAS in adolescents after bariatric surgery.
View Article and Find Full Text PDFIntroduction: There is wide variation in the cost of disposable operating room supplies between surgeons performing the same operation at the same institution. The general relationship between variation in disposable supply cost and patient outcomes is unknown. We aimed to evaluate the relationship between disposable supply cost and patient outcomes for sixteen common operations.
View Article and Find Full Text PDFObjective: Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes.
Methods: We included 63 participants from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort.
Background: Adolescent bariatric surgery produces substantial weight loss and reduction of medical co-morbidities. Research in adult samples shows improved cognitive function postoperatively, although much less is known about the potential cognitive benefits of bariatric surgery in adolescents-especially at extended follow-up.
Objective: Examine cognitive function 10 years after adolescent bariatric surgery.
Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition among children and adolescents, with varying severity levels, including nonalcoholic steatohepatitis (NASH) which features inflammation and fibrosis.
- Researchers investigated the link between plasma microRNA (miRNA) levels and various histological features of NAFLD in adolescents, analyzing samples from 81 affected individuals and 54 healthy controls.
- The study found significant associations between specific upregulated and downregulated miRNAs and features of NAFLD, suggesting that certain miRNAs may play a role in the disease's pathology and could serve as potential biomarkers for NAFLD severity.
Background: Among adolescents who underwent metabolic and bariatric surgery (MBS), it is unclear how relationships and specifically marital status (MS) may be associated with long-term weight loss.
Objective: In this analysis, we tested for associations between the MS of adolescents who underwent MBS and the MS of their primary caregiver and weight loss trajectory over 8 years.
Setting: Teen-LABS participating sites.
Article Synopsis
- Metabolic and bariatric surgery (MBS) in adolescents leads to decreased bone mineral density (BMD) in young adults, specifically affecting the hip and femoral neck.
- A study involving 106 young adults who underwent MBS and 91 controls showed significant reductions in BMD at critical sites like the hip and femur, with the RYGB group displaying more pronounced bone loss.
- The findings highlight that longer time since surgery correlates with lower BMD Z-scores, raising concerns about long-term bone health in this population.
Background: The long-term effect of bariatric surgery on adolescent non-alcoholic fatty liver disease is not clear.
Objectives: To evaluate longitudinal change in serum alanine aminotransferase (ALT) levels and to determine the factors independently associated with this change over 2 years after bariatric surgery in adolescents with severe obesity.
Setting: An observational prospective cohort from the Teen-LABS Consortium.
Objective: Metabolic and bariatric surgery (MBS) is associated with decreased bone mineral density (BMD) in adults. The long-term impact of MBS during adolescence on BMD is unknown. We report bone health status 5 to 11 years after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) from the Teen-LABS study cohort.
View Article and Find Full Text PDFAnimal studies have pointed at the liver as a hotspot for per- and polyfluoroalkyl substances (PFAS) accumulation and toxicity; however, these findings have not been replicated in human populations. We measured concentrations of seven PFAS in matched liver and plasma samples collected at the time of bariatric surgery from 64 adolescents in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. Liver:plasma concentration ratios were perfectly explained ( > 0.
View Article and Find Full Text PDFIntroduction: To gain insights into the mechanisms underlying distinct nonalcoholic fatty liver disease (NAFLD) histological phenotypes between children and adults, we compared hepatic gene expression profiles associated with NAFLD phenotypes between the two age groups.
Methods: Histological characteristics of intra-operative liver biopsies from adolescents and adults undergoing bariatric surgery were assessed by the same pathologist using the non-alcoholic steatohepatitis (NASH) Clinical Research Network scoring system. Hepatic gene expression was measured by microarray analysis.
Article Synopsis
- Glycerol is a key substrate involved in metabolic processes like gluconeogenesis and fatty acid esterification in the liver, which can contribute to fat accumulation in obesity.
- Participants in a study undergoing bariatric surgery consumed labeled glycerol, allowing researchers to analyze its conversion into glutathione and other metabolites in liver tissue.
- Results indicated that glycerol can indeed be incorporated into glutathione, but this synthesis tended to be lower in obese adolescents with liver issues.
Objective: To describe alcohol use, alcohol-related harm, and alcohol-related problems preoperatively and up to 8 years following metabolic and bariatric surgery (MBS) in adolescents.
Background: Risk for alcohol use and alcohol use disorders (AUD) increases post-Roux-en-Y gastric bypass and vertical sleeve gastrectomy in adults. However, data are lacking in adolescents who undergo MBS.
The current paradigm of bariatric surgery in adolescents.
Nat Rev Gastroenterol Hepatol
January 2023
Background: Metabolic syndrome (MetS) affects ∼10% of U.S. adolescents.
View Article and Find Full Text PDFContext: Vertical sleeve gastrectomy (VSG) is an increasingly common tool to achieve weight loss and improve metabolic health in adolescents and young adults with obesity, although it may adversely affect bone health.
Objective: This work aimed to evaluate the effect of VSG on bone health in youth.
Methods: An observational 2-year study was conducted at a tertiary care center of 66 patients aged 13 to 24 years with moderate-to-severe obesity meeting criteria for VSG.
Introduction: This study examined problematic eating and eating-related psychopathology among young adults who underwent adolescent bariatric surgery including concurrent and prospective associations with psychosocial factors and weight change.
Methods: VIEW point is a 6-year follow-up study within a prospective observational study series observing adolescents with severe obesity who had bariatric surgery ( = 139) or who presented to nonsurgical lifestyle modification programs ( = 83). Participants completed height/weight measurements, questionnaires, and diagnostic interviews.
Background: Operating room (OR) costs account for 40% of hospital costs. Disposable supplies make up a portion of OR costs and are the only cost that is under control of the surgeon. There are little data to explain how surgeons select surgical supplies and what factors predict supply selection.
View Article and Find Full Text PDFBackground: It is estimated that 4.5 million youth in the United States have severe obesity (SO). Metabolic and bariatric surgery (MBS) is the most effective and longitudinally durable treatment for adolescents with SO, but only an estimated 1600 adolescents undergo the procedure annually.
View Article and Find Full Text PDFBackground: A standardized approach for identifying and treating hypothalamic obesity (HO) in children with hypothalamic tumours is lacking.
Objectives: To describe children with hypothalamic tumours at risk for obesity, assess outcomes of a novel HO clinical algorithm, and identify factors associated with weight gain.
Methods: Retrospective analysis of youth with hypothalamic and suprasellar tumours, seen at a paediatric tertiary care centre from 2010 to 2020.