Publications by authors named "Thomas Hussey"
Background-Tumour necrosis factor alpha (TNFα) plays an important role in the pathogenesis of inflammatory bowel disease (IBD) and in immunity to Patients should be tested for latent tuberculosis infection using interferon-gamma release assays (IGRA/QF) prior to anti-TNFα therapy. Indeterminate QF results can delay anti-TNFα therapy. We sought to investigate factors associated with indeterminate QF results.
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- Carbonic anhydrase VI (CA VI) plays a role in protecting tooth enamel from cavities by being secreted from salivary glands, and its lower levels are linked to higher cavity rates in humans.
- Research using Car6(-/-) mice, which lack CA VI, showed these mice had unexpectedly fewer caries than normal mice after exposure to the cavity-causing bacteria Streptococcus mutans.
- The study suggests CA VI may actually contribute to cavity development by influencing the oral microbiota and producing acids in dental plaque.