The Triple-negative Breast Cancer Cell Line MDA-MB 231 Is Specifically Inhibited by the Ionophore Salinomycin.

Background/aim: Tumour cells of the profile CD44/CD24 have a high tumorigenic potential. Salinomycin can specifically inhibit the growth of these cells. Herein, we investigated the effects of salinomycin on the viability and migration of triple negative breast cancer cells.

The increased adhesion of tumor cells to endothelial cells after irradiation can be reduced by FAK-inhibition.

Background: Radiotherapy is administered in more than 60% of all solid tumors. Most patients are cured but a significant number develops local recurrences or distant metastases. The question arises if irradiation might influence the metastatic process.

Robo1 and vimentin regulate radiation-induced motility of human glioblastoma cells.

Glioblastoma is a primary brain tumor with a poor prognosis despite of many treatment regimens. Radiotherapy significantly prolongs patient survival and remains the most common treatment. Slit2 and Robo1 are evolutionarily conserved proteins involved in axon guidance, migration, and branching of neuronal cells.

Automated Multichamber Time-lapse Videography for Long-term Observation of Migrating Cells.

Aim: To observe and document the migration of living cells by time-lapse videography, we constructed a low-budget system based on a common inverted microscope.

Materials And Methods: Long-term observation of six-well plates is enabled through maintenance of cell culture conditions (5% CO in air at 37°C). Points of interest can be revisited in definable intervals with <1 μm repositioning error.