Coronary circulatory function with increasing obesity: A complex U-turn.

Aims: The aim of this investigation was to explore and characterize alterations in coronary circulatory function in function of increasing body weight with medically controlled cardiovascular risk factors and, thus, "metabolically" unhealthy obesity.

Materials And Methods: We prospectively enrolled 106 patients with suspected CAD but with normal stress-rest myocardial perfusion on N-ammonia PET/CT and with medically controlled or no cardiovascular risk factors. N-ammonia PET/CT concurrently determined myocardial blood flow (MBF) during pharmacologically induced hyperaemia and at rest.