Safety and robustness of coated pellets: self-healing film properties and storage stability.

Purpose: Aim of the study was to verify the safety of chlorpheniramine maleate pellets, coated with blends of poly(vinyl acetate) and poly(vinyl alcohol)-poly(ethylene glycol) graft copolymer. Therefore, the impact of mechanical forces and storage conditions on the drug release was investigated.

Results: Similar release profiles before and after compression of the pellets to tablets underlined the high film robustness.