Publications by authors named "Thomas H A Samuels"
Introduction: Catastrophic costs incurred by tuberculosis (TB) patients have received considerable attention, however little is known about costs and pathways to care after a negative TB evaluation.
Materials And Methods: We conducted a cross-sectional study of 70 patients with a negative TB evaluation at four community health centres in rural and peri-urban Uganda. Patients were traced 9 months post-evaluation using contact information from TB registers.
Introduction: A highly sensitive triage test that captures most symptomatic patients at increased likelihood of having pulmonary tuberculosis (PTB) would 'rule-out' lower-risk patients from expensive confirmatory testing. Although studies have assessed the diagnostic accuracy of a C-reactive protein (CRP) triage test for PTB in HIV+ patients, limited data are available from HIV- cohorts.
Materials And Methods: In this retrospective case-control study, 765 serum samples were selected from FIND's biobank.
Article Synopsis
- A growing number of prognostic models for COVID-19 are being proposed, but their effectiveness for practical use in clinics is still uncertain.
- The study validated 22 candidate models on 411 COVID-19 patients in hospitals, assessing their ability to predict clinical deterioration and mortality using admission data.
- It found that while the NEWS2 score and a novel model showed promise in predicting deterioration, basic predictors like admission oxygen saturation and patient age proved to be just as effective, with no models significantly outperforming these simple indicators.
Background: There is substantial variation in the reported treatment outcomes for adult tuberculous meningitis (TBM). Data on survival and neurological disability by continent and HIV serostatus are scarce.
Methods: We performed a systematic review and meta-analysis to characterize treatment outcomes for adult TBM.