Publications by authors named "Thomas Guimard"
Infectious aneurysms represent <5 % of cases [1] with a crucial and challenging diagnosis. Staphylococcus, Streptococcus, Enterobacteria are mostly involved but unusual pathogens like Listeria monocytogenes can be responsible. Collecting data of these rare situations allows to improve diagnosis.
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- The study examined a cluster of acute epiglottitis cases in Vendée, France, from October to December 2022, finding it to be an unusual occurrence.
- Six male patients, averaging 42 years old, were hospitalized, with risk factors like smoking and alcohol use prevalent among them; one patient died.
- A significant rise in acute epiglottitis cases was confirmed through various data sources, which coincided with a national increase in the circulation of streptococcus A.
Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial.
EClinicalMedicine
February 2024
Article Synopsis
- The study examined whether Mas-receptor activation by BIO101 could help balance the Renin-Angiotensin System and reduce severe respiratory issues in hospitalized COVID-19 patients.
- It was a double-blind, randomized trial involving 238 participants, with findings showing a 11.4% lower rate of respiratory failure or early death in the BIO101 group compared to placebo.
- Results suggest BIO101 may reduce the risk of severe outcomes in COVID-19 patients, although further research is needed due to the low sample size.
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial.
Lancet Infect Dis
May 2024
Article Synopsis
- This study investigates the effectiveness and safety of switching from intravenous to oral antibiotics after 5-7 days in patients with low-risk Staphylococcus aureus bloodstream infections.
- Conducted across 31 hospitals in Europe, the trial aimed to determine if early oral therapy could maintain patient safety and reduce complications compared to ongoing intravenous treatment.
- Due to slow participant recruitment, the trial was halted early with 215 participants, and the analysis was adjusted to ensure statistical validity, focusing on whether oral treatment led to acceptable complication rates compared with the traditional intravenous approach.
Article Synopsis
- - The study assessed XAV-19, an antibody treatment, for hospitalized COVID-19 patients with severe symptoms, focusing on its safety and effectiveness in preventing death or serious respiratory failure.
- - Conducted across 34 hospitals in France, the trial involved 398 adult patients who were randomly assigned to receive either XAV-19 or a placebo, with no major differences in outcomes observed between the two groups after 15 days.
- - Findings revealed that treatment with XAV-19 did not lead to a significant reduction in the incidence of severe health complications compared to placebo, and adverse events were similarly reported in both groups.
Staphylococcus aureus surgical site infection rates in 5 European countries.
Antimicrob Resist Infect Control
September 2023
Objective: To determine the overall and procedure-specific incidence of surgical site infections (SSI) caused by Staphylococcus aureus (S. aureus) as well as risk factors for such across all surgical disciplines in Europe.
Methods: This is a retrospective cohort of patients with surgical procedures performed at 14 European centres in 2016, with a nested case-control analysis.
Tularemia is a zoonotic infection caused by Francisella tularensis. Its most typical manifestations in humans are ulceroglandular and glandular; infections in prosthetic joints are rare. We report 3 cases of F.
View Article and Find Full Text PDFBackground: Community Acute Bacterial Meningitis (CABM) is a rare infectious disease leading to important impairments. Our aim was to describe CABM survivors' quality of life (QOL) 12 months post-CABM and to assess its associations with CABM sequelae.
Methods: Patients included in the CABM COMBAT cohort were evaluated one year after the CABM episode.
Article Synopsis
- * A study of 67 patients over 19 years in France identified the main infectious strains as V. alginolyticus, V. parahaemolyticus, and others, with significant drug resistance observed.
- * 36% of patients experienced severe outcomes like septic shock or death, highlighting the need for doctors to consider vibriosis in at-risk patients.
Article Synopsis
- Enterococcus faecalis infective endocarditis (EFIE) has a higher relapse rate compared to other types of infective endocarditis, and this study explores the influence of different antibiotic treatments on these relapses.
- The research involved 279 patients from 14 hospitals in France, analyzing the occurrence of relapses within one year following diagnosis, using specific statistical models to account for competing risks like death.
- Results showed that relapses are common (9.3% in one year) and can even be asymptomatic, with surgery during treatment noted as a protective factor; the relapse rates varied significantly based on the type of antibiotic regimen used.
Article Synopsis
- Researchers tested whether anakinra, a drug for blocking interleukin-1 receptors, could help moderate COVID-19 patients requiring oxygen treatment.
- In a trial with 71 enrolled patients, those receiving anakinra had lower treatment success and higher mortality at 28 days compared to those receiving standard care.
- The study concluded that anakinra was not effective and even proved to be worse than standard care for treating moderate COVID-19 pneumonia.
Among 40 patients diagnosed with leptospirosis in 3 hospitals of western mainland France between 2014 and 2018, half were at least 60 years old and retired. Their exposure factors were mainly rural residential environment with limited remarkable risk factors. Better awareness and information on leptospirosis appear necessary in this population.
View Article and Find Full Text PDFObjectives: To determine whether hydroxychloroquine decreases the risk of adverse outcome in patients with mild to moderate coronavirus disease 2019 (COVID-19) at high risk of worsening.
Methods: We conducted a multicentre randomized double-blind placebo-controlled trial evaluating hydroxychloroquine in COVID-19 patients with at least one of the following risk factors for worsening: need for supplemental oxygen, age ≥75 years, age between 60 and 74 years and presence of at least one co-morbidity. Severely ill patients requiring oxygen therapy >3 L/min or intensive care were excluded.
Background: We describe the epidemiological, clinical, and prognostic aspects of 177 tularemia cases diagnosed at the National Reference Center for rickettsioses, coxiellosis, and bartonelloses between 2008 and 2017.
Methods: All patients with a microbiological diagnosis of tularemia made in the laboratory were included. Clinical and epidemiological data were collected retrospectively from clinicians in charge of patients using a standardized questionnaire.
Infectious aortitis (IA) is a rare and severe disease. The treatment classically associates open surgery with prolonged antibiotic therapy. This study aimed to describe clinical characteristics, medical and surgical supports in a large and current series of IA.
View Article and Find Full Text PDFHigh-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram.
Antimicrob Agents Chemother
September 2019
High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled in a French multicenter prospective cohort study who received high-dose ceftriaxone for CNS infection as recommended by French guidelines (75 to 100 mg/kg of body weight/day without an upper limit).
View Article and Find Full Text PDFBackground: Ceftriaxone is widely used to treat community-acquired CNS bacterial infections. French guidelines for meningitis in adults promote 75-100 mg/kg/day ceftriaxone without an upper limit for dosage, yet little is known about the pharmacology and tolerability of such regimens.
Patients And Methods: A multicentre prospective cohort study was conducted in adult patients to assess the adverse drug reactions (ADRs) of high-dose ceftriaxone (i.
-like bacteria have been recently proposed as human pathogens. Using molecular techniques, we detected like bacteria in the blood and serum samples of a patient with a scalp eschar, neck lymphadenopathy, severe urticaria, edema, fever, and arthralgia indicating that this organism can provide systemic complications.
View Article and Find Full Text PDFBackground: Coxiella burnetii endocarditis is considered to be a late complication of Q fever in patients with preexisting valvular heart disease (VHD). We observed a large transient aortic vegetation in a patient with acute Q fever and high levels of IgG anticardiolipin antibodies (IgG aCL). Therefore, we sought to determine how commonly acute Q fever could cause valvular vegetations associated with antiphospholipid antibody syndrome, which would be a new clinical entity.
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- Sleep disturbances are common in HIV-infected patients, with 47% reporting issues, especially among women and those experiencing depression.
- A study in France assessed 1,354 HIV patients using questionnaires to gather data on sleep quality, quality of life, and depression.
- Key factors linked to sleep disturbances included depression, being single, and smoking, while active employment and male gender seemed to reduce risk.
[Elderly subjects hospitalised in acute care medical unit: baseline date and on-year follow-up].
Geriatr Psychol Neuropsychiatr Vieil
March 2012
Objectives: To describe the elderly population hospitalized in a service of short-term care, and to follow during one year its evolution in term of dependence and of rehospitalisation.
Methods: Inclusion of all the patients of more than 75 years hospitalized in the service during 5 weeks, with initial geriatric evaluation, and phone evaluation in 6 months and one year.
Results: Seventy-four patients were included, among which 57 were living at home.