Publications by authors named "Thomas Grasbon"
Background: Controversy still surrounds the intravenous (IV) treatment of endophthalmitis. The purpose of this study was to compare IV and intraocular (IO) treatment in experimental Staphylococcus aureus endophthalmitis: intravitreal injection of vancomycin and amikacin (VA/AN) in comparison with IV imipenem (IPM) and a combination of IV and IO (IV+IO) therapy.
Methods: The right eyes of 27 rabbits were injected with 25000 S.
Background: To compare the efficacy of intravenous (IV) imipenem (IPM) and a combination of IV ceftazidime (CAZ) and amikacin (AN) in the treatment of Staphylococcus aureus endophthalmitis in a rabbit model.
Methods: Right eyes of 60 albino rabbits were injected with 1000 colony-forming units of S. aureus intravitreally.
Purpose: In vitreoretinopathy membranes and in vitro, RPE cells lose pigment and transform into fibroblast-like cells. The purpose of this study was to investigate whether the immune privileged status of different eye compartments influence morphological changes of adult RPE cell transplants.
Methods: RPE cells from adult C57BL/6 mice were transplanted either intravitreally (n = 31), subretinally (n = 28), intrachoroidally (n = 21) or subconjunctivally (n = 33) into one eye of BALB/c mice and intravitreally (n = 5) into rd-mice with loss of ACAID (14-16 months).
Intravenous imipenem prophylaxis in experimental endophthalmitis.
Graefes Arch Clin Exp Ophthalmol
July 2002
Purpose: To determine the effect of prophylactic intravenous imipenem on experimental Staphylococcus aureusendophthalmitis.
Methods: The right eyes of 36 New Zealand albino rabbits received an intraocular injection of 100, 1,000, or 10,000 colony-forming units (CFU) of S. aureus.
Objective: To compare a new rapid antibiotic susceptibility test (RAST) to the conventional method in patients with endophthalmitis.
Design: Prospective nonrandomized comparative trial.
Participants: Intraocular aspirates from 24 consecutive patients with endophthalmitis were tested.