Superheated reversed phase chromatography with ultrashort columns for the analysis of therapeutic proteins.

Mild or elevated temperatures are routinely used for the analysis of therapeutic proteins by reversed phase liquid chromatography. Generic conditions can be used for the analysis of monoclonal antibodies, and may be adapted for species derived thereof, for instance their immuno-conjugates. Beyond platform monoclonal antibodies, many novel, non-covalent protein complexes are also frequently pursued as protein therapeutics.

Magnetic strength and corrosion of rare earth magnets.

Introduction: Rare earth magnets have been used in orthodontics, but their corrosion tendency in the oral cavity limits long-term clinical application. The aim of this project was to evaluate several; magnet coatings and their effects on magnetic flux density.

Methods: A total of 60 neodymium-iron-boron magnets divided into 6 equal groups--polytetrafluoroethylene-coated (PTFE), parylene-coated, and noncoated--were subjected to 4 weeks of aging in saline solution, ball milling, and corrosion testing.

Repair of orthodontically induced root resorption by ultrasound in humans.

Root resorption is an adverse outcome of orthodontic tooth movement. In addition to the iatrogenic response and compromising the crown-root ratio, root resorption has led to increased malpractice litigation against orthodontists. A clinically acceptable method of treating root resorption has not been validated in the literature to date.

Structure and function of the emergency department: matching emergency department choices to the emergency department mission.

Emergency caregivers experience considerable new challenges to the provision of competent, compassionate care. The good news is there are ample new approaches and new technologies to meet those new challenges.ED leaders who understand the ED mission and the resources available today and who engage vigorously in the change process will turn that mission into immensely beneficial action.

Growth modification of the rabbit mandible using therapeutic ultrasound: is it possible to enhance functional appliance results?

Previous studies have shown that functional appliances can enhance mandibular growth when applied during the active growth period. However, besides patient compliance problems with bulky appliances and prolonged treatment demands, there is contradictory evidence that functional appliances have a significant long-term effect. Is there a method to enhance the growth response and improve the long-term success of functional appliances? Previous studies have also found that therapeutic ultrasound (US) can stimulate cartilage and bone growth.

Cuyahoga County Operation Stroke speed of emergency department evaluation and compliance with National Institutes of Neurological Disorders and Stroke time targets.

Background And Purpose: Although the National Institutes of Neurological Disorders and Stroke (NINDS) has established time targets for the evaluation of acute stroke patients, little is known about how often these targets are met in the community. To track compliance with NINDS guidelines, Cuyahoga County Operation Stroke implemented a countywide data collection process that provides comparative reporting of hospital performance.

Methods: Data on the emergency department evaluation of stroke patients have been retrospectively collected since January 2000 by hospitals participating in Cuyahoga County Operation Stroke.

Orthodontics and temporomandibular disorder: a meta-analysis.

As the importance of evidence-based health care has grown, meta-analysis has become more widely used in the medical and dental fields. In this meta-analysis, the relationship between traditional orthodontic treatment, including the specific type of appliance used and whether extractions were performed, and the prevalence of temporomandibular disorders (TMD) was investigated. After an exhaustive literature search of 960 articles, we found 31 that met the inclusion criteria (18 cross-sectional studies or surveys and 13 longitudinal studies).