Optic neuritis in Turkish children and adolescents: A multicenter retrospective study.

Background: Various etiologies may underlie optic neuritis, including autoantibody-mediated disorders described in the last decade. We re-examined demographic, clinical, laboratory features and prognostic factors in pediatric patients with autoimmune optic neuritis according to current knowledge.

Methods: Cases of pediatric ON from 27 centers in Türkiye diagnosed between 2009 and 2022 were included for retrospective evaluation.

Evaluation of vincristine-induced peripheral neuropathy in children with cancer: Turkish validity and reliability study.

Background: The evaluation of peripheral neuropathy in children receiving Vincristine treatment is challenging. This study examined the Turkish validity and reliability of the Total Neuropathy Score-Pediatric Vincristine (TNS-PV) measurement tool, which can measure Vincristine-induced peripheral neuropathy symptoms in children with cancer.

Methods: A total of 53 children aged 5-17 years who received Vincristine treatment in two pediatric hematology-oncology centers participated in the study.

Examination of the psychometric properties of pediatric-modified total neuropathy score in Turkish children with cancer.

Background: Evaluation of chemotherapy-induced peripheral neuropathy has gained importance in symptom management of pediatric patients with cancer. This study aimed to perform the Turkish validity and reliability study of the Pediatric-Modified Total Neuropathy Score (Ped-mTNS).

Methods: A methodological, descriptive, and cross-sectional design was used in the study.

Judgments of a Product's Quality and Perceptions of User Experience Can Be Mediated by Brief Messaging That Matches the Person's Pre-existing Attitudes.

The mediation of an attitude to a product following a brief message is investigated. Statements indicating whether a computer was running on energy from renewable or more conventional sources were presented and users' experiences were measured. Participants' pre-existing environmental concern and the satisfaction they expressed with the computers were related, but only when the "renewable energy" message was presented.

The English Plastic Bag Charge Changed Behavior and Increased Support for Other Charges to Reduce Plastic Waste.

Plastic bags create large amounts of waste and cause lasting environmental problems when inappropriately discarded. In 2015, England introduced a mandatory five pence (US$0.06/€0.

The impact of parenthood on environmental attitudes and behaviour: a longitudinal investigation of the legacy hypothesis.

Willingness to engage in sustainable actions may be limited by the psychological distance of climate change. In this study, we test the , which holds that having children leads parents to consider the legacy left to offspring in respect of environmental quality. Using the Understanding Society dataset, a longitudinal survey representative of the UK population ( = 18,176), we assess how having children may change people's individual environmental attitudes and behaviour.

Habit Discontinuity, Self-Activation, and the Diminishing Influence of Context Change: Evidence from the UK Understanding Society Survey.

Repeated behaviours in stable contexts can become automatic habits. Habits are resistant to information-based techniques to change behaviour, but are contextually cued, so a change in behaviour context (e.g.

High liver content of polybrominated diphenyl ether (PBDE) in otters (Lutra lutra) from England and Wales.

Polybrominated diphenyl ethers (PBDEs), used as flame retardants since the 1970s, are being phased out of use, but are persistent and widespread in the environment. Historical declines in Eurasian otter (Lutra lutra) populations have been associated with exposure to dieldrin and polychlorinated biphenyls (PCBs), but links with other persistent organic pollutants have not been explored. In this study, liver samples from 129 otters, collected across England and Wales from 1995-2006, were analysed for PBDEs, together with PCBs, DDT breakdown products, and hexachlorobenzene.

The role of the quality assessment in the determination of overall biosimilarity: a simulated case study exercise.

A determination of biosimilarity is based on a thorough characterization and comparison of the quality profiles of a similar biotherapeutic product and its reference biotherapeutic product. Although the general principles on the role of the quality assessment in a biosimilar evaluation are widely understood and agreed, detailed discussions have not been published yet. We try to bridge this gap by presenting a case study exercise based on fictional but realistic data to highlight key principles of an evaluation to determine the degree of similarity at the quality level.

A pre-hospital technique for controlling haemorrhage from traumatic perineal and high amputation injuries.

Perineal trauma resulting from the adaptive use of improvised explosive devices (IEDs) has become an increasingly common problem during current operational conflicts in Afghanistan. Control of haemorrhage from the perineum and high amputations is a particular challenge due to the bony anatomy, rich pelvic vascular supply and the difficulty in achieving haemostasis by direct pressure. In this article, the authors describe a potential pre-hospital solution for controlling haemorrhage from perineal and high amputation injuries.

Massive transfusion.

Massive Transfusion is a part of Damage Control Resuscitation. The aim of transfusion therapy is to restore oxygen delivery to poorly perfused tissues and to treat the acute coagulopathy of trauma. The severity and complexity of modern injuries have led to the use of swift, protocol-driven care with the use of'Shock Packs' and management of metabolic complications.

Vascular access on the 21st century military battlefield.

Timely and appropriate access to the vascular circulation is critical in the management of 21st century battlefield trauma. It allows the administration of emergency drugs, analgesics and rapid replacement of blood volume. Methods used to gain access can include; the cannulation of peripheral and central veins, venous cut-down and intraosseus devices.

Dual actions of lindane (γ-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells.

The persistent organochlorine pesticide lindane is still abundantly found in the environment and in human and animal tissue samples. Lindane induces a wide range of adverse health effects, which are at least partially mediated via the known inhibition of GABA(A) and glycine receptors. Additionally, lindane has been reported to increase the basal intracellular Ca(2+) concentration ([Ca(2+)](i)).

Battlefield resuscitation.

Purpose Of Review: To bring together in one review article, the most current and relevant evidence relating to military trauma resuscitation.

Recent Findings: The main themes highlighted by this review are coagulopathy of trauma shock (CoTS), damage control resuscitation, haemostatic resuscitation, the management of massive transfusion, use of adjuvant drugs for haemostasis and use of an empiric massive transfusion protocol.

Summary: The review aims to educate the readership in recent advances in trauma practice, culminating in a novel empiric massive transfusion algorithm seamlessly guiding the clinician through the initial resuscitation stage resulting in reduced mortality, morbidity, coagulopathy and decreased overall blood product usage.

Exposure to persistent organic pollutants and first-year survival probability in gray seal pups.

Many studies have demonstrated that persistent organic pollutants are transferred from mother to pup during lactation in phocid seals, but none have been able to determine the significance of these findings for survivorship. The aim of this study was to investigate the relationship between blubber contaminant concentrations and first-year survival in gray seal pups. A mark-recapture framework was used to estimate survival probabilities and animals were "marked" using novel mobile phone tags.

Polybrominated diphenyl ether-associated alterations in cell biochemistry as determined by attenuated total reflection Fourier-transform infrared spectroscopy: a comparison with DNA-reactive and/or endocrine-disrupting agents.

Whether polybrominated diphenyl ethers (PBDEs) induce effects in target cells is increasingly important given that their environmental burdens are rising. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy can be used to biochemically signature cells based on the notion that a detailed "biochemical-cell fingerprint" in the form of an infrared (IR) spectrum is derived. By employing subsequent computational approaches such as principal component analysis (PCA) and/or linear discriminant analysis (LDA), data reduction is achieved to allow for the identification of wavenumber-related biomarkers of effect Clustering of similar spectra (or scores) away from dissimilar ones highlights the variance responsible for discriminating classes.

A mass balance of tri-hexabrominated diphenyl ethers in lactating cows.

Beef and dairy products can be important vectors of human exposure to polybrominated diphenylethers (BDEs), and hence an understanding of BDE transfer from feed to cows' milk and tissue is important for BDE exposure assessment The fate of tri- to hexaBDEs in lactating cows exposed to a naturally contaminated diet was studied by analyzing feed, feces, and milk samples from a mass balance study. Tissue distribution was studied in one cowslaughtered afterthe experiment The carryover rates from feed to milk ranged from 0.15 to 0.

Flame acceleration and the development of detonation in fuel-oxygen mixtures at elevated temperatures and pressures.

Experimental measurements of the conditions required for the development of detonation in a 7 mm tube following ignition by a low energy spark are reported. There are then compared to previous experimental propagation limit criterion using theoretical predictions of detonation cell sizes based on a one-dimensional detonation length scale computed using a detailed chemical kinetic scheme. Technical difficulties precluded direct cell size measurements.

Uptake and storage of PCBs by plant cuticles.

The uptake kinetics and storage of PCBs by isolated cuticles and cuticular waxes from Hedera helix, Prunus laurocerasus, and Ilex aquifolium were studied. Small chambers were used, allowing variation in plant uptake parameters to be studied by having the same air boundary layer in each chamber. During the 64 day study tri- and tetrachlorinated biphenyls generally reached equilibrium in waxes but not in whole cuticles.

Use of two-photon excitation microscopy and autofluorescence for visualizing the fate and behavior of semivolatile organic chemicals within living vegetation.

The uptake, transport, storage, and processing of semivolatile organic chemicals (SVOCs) by vegetation plays an important role in their environmental fate. Understanding these processes at the plant cellular level is essential to understanding the fate and behavior of SVOCs within the environment. Traditional analytical methods have relied on destructive analysis of the plant and a level of inference to suggest exactly where within the plant the chemical is residing, how it is getting there, and what its subsequent fate might be.

Validation of a passive atmospheric deposition sampler for polybrominated diphenyl ethers.

An atmospheric deposition sampler was validated with respect to polybrominated diphenyl ethers (PBDEs), a compound group that is widely used as flame retardants in many types of consumer products. The deposition sampler consists of an adsorption cartridge that is connected to a glass funnel. Extraction tests with spiked cartridges using soxhlet extraction with acetone revealed recoveries of >80% for all of the investigated PBDEs.

Decabromodiphenyl ether (deca-BDE) commercial mixture components, and other PBDEs, in airborne particles at a UK site.

The occurrence of the major components of the decabromodiphenyl ether (deca-BDE) flame retardant and other PBDEs was investigated in daily air particulate samples from 17th April to 20th May 2004 at a semi-rural site in north-west England. BDE-209 was found at between <0.49 and 100 pg m(-3) (median 13 pg m(-3)), and other higher-brominated PBDE congeners were also found, particularly the nona-BDEs (e.

PAHs in background soils from Western Europe: influence of atmospheric deposition and soil organic matter.

The levels and distribution of polynuclear aromatic hydrocarbons (PAHs) were determined in soil samples from background locations in the UK and Norway, to investigate their spatial distribution and the controlling environmental factors. Concentrations ranged between 42 and 11200 microg kg(-1) (geometric mean 640 microg kg(-1)) and 8.6 and 1050 microg kg(-1) (150 microg kg(-1)) dry weight in the UK and Norwegian soil, respectively.