Publications by authors named "Thomas G Van Dinter"

Article Synopsis
  • Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) was studied to see if it correlates with fat malabsorption in severely obese patients.
  • Before RYGB, patients had mild to moderate steatorrhea but no correlation between fecal fat and urine oxalate excretion was found, while after RYGB, steatorrhea and urine oxalate increased significantly with a positive correlation.
  • The study suggests that while hyperoxaluria was common pre-bypass, it was likely not due to excess unabsorbed fats, but possibly driven by other factors like obesity or metabolic syndrome, with a more direct correlation observed post-surgery.
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A 57-year-old woman, who had undergone Roux-en-Y gastric bypass surgery 9 years earlier, was admitted to the intensive care unit because of pneumonia. Despite antibiotic therapy, she died 40 days later, apparently because of sepsis and organ failure related to the pneumonia. However, the patient's family requested an autopsy, which revealed that her death was due to perforation of the Roux limb of her gastric bypass, which had resulted in severe peritonitis.

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A 55-year-old white woman with a greater than 25-year history of Crohn's disease developed disseminated aspergillosis following combination therapy with Methylprednisolone, azathioprine, and infliximab. The patient was hospitalized 11 days after initiation of infliximab for respiratory symptoms and developed respiratory failure, coma, and died. Postmortem examination revealed disseminated Aspergillus fumigatus involving multiple organs.

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Background & Aims: Secretory diarrhea is caused by inhibition of intestinal active sodium absorption and stimulation of active chloride secretion. The resulting increase in fecal sodium salts causes an isotonic increase in fecal water output. Abnormalities in potassium transport are not known to be a cause of secretory diarrhea.

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