Publications by authors named "Thomas G McNary"

Article Synopsis
  • Clerkships are critical for medical students to combine their basic science knowledge with hands-on clinical practice, particularly in anatomy, which is vital for effective patient care.
  • Concerns persist about medical students' anatomy knowledge falling short of the expectations of clerkship directors and clinical faculty, indicating a potential gap in training.
  • A study surveying 525 clinical faculty across 24 schools identified that 91% of anatomical structures are deemed essential for core clerkships, highlighting specific anatomy needs for clerkships like family medicine, emergency medicine, and general surgery.
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In most mammalian cardiomyocytes, the transverse tubular system (t-system) is a major site for electrical signaling and excitation-contraction coupling. The t-system consists of membrane invaginations, which are decorated with various proteins involved in excitation-contraction coupling and mechano-electric feedback. Remodeling of the t-system has been reported for cells in culture and various types of heart disease.

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The transverse tubular system (t-system) is a major site for signaling in mammalian ventricular cardiomyocytes including electrical signaling and excitation-contraction coupling. It consists of membrane invaginations, which are decorated with various proteins including mechanosensitive ion channels. Here, we investigated mechanical modulation of the t-system.

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