The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression.

The Fn14 gene encodes a type Ia transmembrane protein that belongs to the tumor necrosis factor receptor superfamily. We recently showed that fibroblast growth factor-inducible 14 (Fn14) is overexpressed in migrating glioma cells in vitro and in glioblastoma multiforme clinical specimens in vivo. To determine the biological role of Fn14 in brain cancer progression, we examined the activity of Fn14 as a potential mediator of cell survival.

Allocation of attention and production of time intervals.

14 students enrolled in introductory psychology classes engaged in several trials of card sorting to acquire the rule for correct sorting. They also were instructed to keep track of time simultaneously and to continue sorting for what they believed was 20 sec. The duration of card sorting was significantly greater for the first sorting trial, during which the rule was unknown, relative to the second consecutive trial of errorless sorting when the rule had been learned.