Modification of Diet to Reduce the Stemness and Tumorigenicity of Murine and Human Intestinal Cells.

Scope: Black raspberries (BRBs) have colorectal cancer (CRC) chemo-preventative effects. As CRC originates from an intestinal stem cell (ISC) this study has investigated the impact of BRBs on normal and mutant ISCs.

Methods And Results: Mice with an inducible Apc mutation in either the ISC (Lgr5CreER ) or intestinal crypt (AhCre/VillinCreER ) are fed a control or 10% BRB-supplemented diet.