Publications by authors named "Thomas E Maher"
The discovery of new compounds with pharmacological properties is usually a lengthy, laborious and expensive process. Thus, there is increasing interest in developing workflows that allow for the rapid synthesis and evaluation of libraries of compounds with the aim of identifying leads for further drug development. Herein, we apply combinatorial synthesis to build a library of 90 iridium(III) complexes (81 of which are new) over two synthesise-and-test cycles, with the aim of identifying potential agents for photodynamic therapy.
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- - Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are linked neurodegenerative diseases, with the C9orf72 gene mutation being a common genetic cause due to the repeat of a hexanucleotide sequence (GGGGCC).
- - The research found that this GGGGCC sequence forms complex structures known as multimolecular G-quadruplexes (mG4s), which aggregate and contribute to the development of condensate formations associated with these diseases.
- - Increased levels of these G-quadruplex structures were detected in motor neurons from individuals with the C9orf72 mutation compared to healthy neurons, indicating that targeting these condensates could offer new therapeutic options for ALS/FTD.
Unprecedented bacterial targets are urgently needed to overcome the resistance crisis. Herein we systematically mine pyridoxal phosphate-dependent enzymes (PLP-DEs) in bacteria to focus on a target class which is involved in crucial metabolic processes. For this, we tailored eight pyridoxal (PL) probes bearing modifications at various positions.
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