Publications by authors named "Thomas Dewar"
Background: Colonoscopy has been adopted as the preferred method to screen for colorectal neoplasia in the United States. However, lesions can be missed because of numerous factors, including location on the proximal aspect of folds or flexures, where they may be difficult to detect with the forward-viewing colonoscope. The Third Eye Retroscope (TER) is a disposable device that is passed through the instrument channel of a standard colonoscope to provide a retrograde view that complements the forward view of the colonoscope during withdrawal.
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- The Adenoma Prevention with Celecoxib Trial studied celecoxib, a Cox-2 inhibitor, for preventing colorectal adenomas in high-risk patients, comparing it to a placebo.
- Results indicated that celecoxib significantly reduced adenoma incidence but raised the risk of cardiovascular events compared to placebo.
- An extension of the study found similar rates of adverse events across groups, but higher risks of cardiovascular issues for those taking celecoxib, particularly for patients with a history of heart disease.
Background: Studies showing that drugs that inhibit cyclooxygenase-2 (COX-2) reduce the number of colorectal adenomas in animals and patients with familial adenomatous polyposis suggest that COX-2 inhibitors may also prevent sporadic colorectal neoplasia.
Methods: We randomly assigned patients who had adenomas removed before study entry to receive placebo (679 patients) or 200 mg (685 patients) or 400 mg (671 patients) of celecoxib twice daily. Randomization was stratified for the use of low-dose aspirin.