Size-controlled antimicrobial peptide drug delivery vehicles through complex coacervation.

Due to the escalating threat of the pathogens' capability of quick adaptation to antibiotics, finding new alternatives is crucial. Although antimicrobial peptides (AMPs) are highly potent and effective, their therapeutic use is limited' as they are prone to enzymatic degradation, are cytotoxic and have low retention. To overcome these challenges, we investigate the complexation of the cationic AMP colistin with diblock copolymers poly(ethylene oxide)--poly(methacrylic acid) (PEO--PMAA) forming colistin-complex coacervate core micelles (colistin-C3Ms).