Publications by authors named "Thomas Damm Als"
Article Synopsis
- Tic disorders (TD) can significantly affect individuals and society, and understanding their genetic causes could lead to better treatments, as family history is a key risk factor.
- A large-scale GWAS meta-analysis was conducted with nearly 10,000 TD cases and over 981,000 controls, revealing a significant genetic association, though it couldn't be replicated in another study.
- The findings suggest a complex genetic landscape for TD, highlighting certain genes and brain regions involved, but additional research is needed to firmly establish reliable genetic links.
Article Synopsis
- Four GWAS studies on obsessive-compulsive disorder (OCD) have been conducted, showing a SNP-heritability of 28% but revealing only one significant SNP so far.
- A new meta-analysis significantly increased the sample size to analyze 37,015 OCD cases against 948,616 controls, identifying 15 independent genome-wide significant loci, 14 of which were novel.
- The research highlighted genetic correlations between OCD and various psychiatric disorders, while also mapping the genetic basis and biological pathways associated with OCD susceptibility.
Among patients with obsessive-compulsive disorder (OCD), 65-85% manifest another psychiatric disorder concomitantly or at some other time point during their life. OCD is highly heritable, as are many of its comorbidities. A possible genetic heterogeneity of OCD in relation to its comorbid conditions, however, has not yet been exhaustively explored.
View Article and Find Full Text PDFNonrandom mating in parents with schizophrenia or bipolar disorder increases the population-level genetic variance among the offspring generation and creates familial (risk) environments likely to be shaped by specific conditions. The objective of this study was to investigate the occurrence of mental disorder and levels of cognitive and social functioning in individuals who have children by partners with schizophrenia or bipolar disorder compared to controls. The Danish High Risk and Resilience Study VIA 7 is a population-based cohort study conducted in Denmark between 2013 and 2016.
View Article and Find Full Text PDFThe salmonid fish Brown trout is iconic as a model for the application of conservation genetics to understand and manage local interspecific variation. However, there is still scant information about relationships between local and large-scale population structure, and to what extent geographical and environmental variables are associated with barriers to gene flow. We used information from 3,782 mapped SNPs developed for the present study and conducted outlier tests and gene-environment association (GEA) analyses in order to examine drivers of population structure.
View Article and Find Full Text PDFAims: 1) To investigate whether genetic liability to attention-deficit/hyperactivity disorder (ADHD), indexed by polygenic risk scores for ADHD (PRS-ADHD), is associated with substance use disorders (SUD) in individuals with ADHD. 2) To investigate whether other individual- or family-related risk factors for SUD could mediate or confound this association.
Design: Population-based cohort study SETTING AND PARTICIPANTS: ADHD cases in the iPSYCH sample (a Danish case-cohort sample of genotyped cases with specific mental disorders), born in Denmark between 1981 and 2003 (N = 13 116).
Introduction: To investigate the impact of a polygenic risk score for schizophrenia (PRS-SZ) and urbanicity on the risk of treatment-resistant schizophrenia (TRS) in people diagnosed with schizophrenia and to evaluate the association between PRS-SZ and TRS across levels of urbanicity.
Methods: Cohort study of people born after 1981 with a first registered diagnosis of schizophrenia between 1996 and 2012 using Danish population registry data. Through linkage to genome-wide data, we calculated PRS-SZ based on a Psychiatric Genomics Consortium meta-analysis.
Importance: Anxiety and stress-related disorders are among the most common mental disorders. Although family and twin studies indicate that both genetic and environmental factors play an important role underlying their etiology, the genetic underpinnings of anxiety and stress-related disorders are poorly understood.
Objectives: To estimate the single-nucleotide polymorphism-based heritability of anxiety and stress-related disorders; to identify novel genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits; and to evaluate the association of psychiatric comorbidities with genetic findings.
Objective: The population of the Faroe Islands in the North Atlantic Ocean is likely to have the same ancestry as the Icelandic population. An Icelandic study on Panic Disorder has found some evidence for a loci on chromosome 9.
Methods: On the Faroe Islands we have an ongoing genetic project concerning panic disorder among other psychiatric disorders.