Publications by authors named "Thomas D Nguyen"
Article Synopsis
- - This study presents a new method using hybrid machine-learning techniques to optimize combination antibiotic therapies by analyzing human and in vitro data together.
- - Researchers focused on three antibiotics—aztreonam, ceftazidime/avibactam, and polymyxin B—using a genetic algorithm to create effective treatment regimens while balancing efficacy and toxicity.
- - The findings demonstrated that machine-learning optimization could produce effective dosage regimens for treating drug-resistant Klebsiella pneumoniae infections, offering a fresh perspective on antibiotic treatment strategies.
Bacteriophage (phage) therapy is being explored as a possible response to the antimicrobial resistance public health emergency. Administering a mixture of different phage types as a cocktail is one proposed strategy for therapeutic applications, but the optimal method for formulating phage cocktails remains a major challenge. Each phage strain has complex pharmacokinetic/pharmacodynamic (PK/PD) properties which depend on the nano-scale size, target-mediated, self-dosing nature of each phage strain, and rapid selection of resistant subpopulations.
View Article and Find Full Text PDFStudy Objective: The objective was to compare tacrolimus AUC determined by Non-Compartmental Analysis (NCA) using intensive sampling to Maximum a Posteriori-Bayesian (MAP-Bayesian) estimates from robust (n = 9 samples/subject) and sparse (n = 2 samples/subject) sampling in 67 stable KTRs and a validation group of similar patients.
Design: This open-label, prospective, single center 12-h PK study included nine serial samples collected in KTRs to determine steady-state NCA tacrolimus AUC .
Setting: This study was conducted at a single site within a large, urban hospital in the western New York area.
The emergence of mobile colistin resistance ()-mediated polymyxin resistance has resulted in a significant detriment to the utility of the polymyxins in the clinical setting. Though the risk for horizontal transfer of an -containing plasmid is a major component of the transmissibility, selection of polymyxin resistant subpopulations is still a major risk factor for developing polymyxin-resistant infections. Using static time-kills over 24 h (h), we performed competition studies by mixing known inocula of isogenic strains (wildtype [WT] and -harboring) and treating with a concentration array of polymyxin B.
View Article and Find Full Text PDFRecent updates in the therapeutic drug monitoring (TDM) guidelines for vancomycin have rekindled interest in maximum a posteriori-Bayesian (MAP-Bayesian) estimation of patient-specific pharmacokinetic parameters. To create a versatile infrastructure for MAP-Bayesian dosing of vancomycin or other drugs, a freely available, R-based software package, Advanced Dosing Solutions (AdDS), was created to facilitate clinical implementation of these improved TDM methods. The objective of this study was to utilize AdDS for pre- and post-processing of data in order to streamline the therapeutic management of vancomycin in healthy and obese veterans.
View Article and Find Full Text PDFArticle Synopsis
- Extinction rates are increasing, and traditional conservation methods might not be enough to save many endangered species.
- The creation of induced pluripotent stem cells (iPSCs) from endangered species, like the northern white rhinoceros, could help retain genetic diversity and assist in future conservation efforts.
- Researchers generated iPSCs from frozen fibroblasts and confirmed their potency, paving the way for using advanced reproductive techniques to potentially repopulate endangered species in the long term.