First exposure to home therapy options--where, when, and how.

Pre-dialysis education is known to impact modality choice among patients with end stage renal disease, but many of these patients report a lack of education in alternative dialysis therapies. Since 2004, Satellite Healthcare, a non-profit dialysis provider, has implemented chronic kidney disease education through Options classes at WellBound Centers, resulting in 23% of patients being treated with home therapies. The Satellite Healthcare-WellBound experience confirms that Options classes and a compelling infrastructure for home dialysis therapies are vital elements to bring alternative dialysis therapies to more patients.

A comparative analysis of the role of water in the binding pockets of ionotropic glutamate receptors.

The binding pockets within proteins often contain water molecules. The ligand-binding core of ionotropic glutamate receptors represents an example where the binding pocket has many crystallographically reported waters, but the precise role remains unclear. It is also unclear to what extent the dynamic properties of these waters are conserved across the different receptor subtypes.