Transnasal, transfacial, anterior skull base resection of olfactory neuroblastoma.

Purpose: Using a transnasal, transfacial, anterior skull base approach, we have removed olfactory neuroblastomas (OFN) obviating the need for a frontal craniotomy. The objectives were to present our surgical approach in achieving clear margins, to assess patient survival, and to recommend eligibility criteria.

Materials And Methods: A retrospective chart review was done to identify patients diagnosed with OFN who underwent this surgical approach.

Parapharyngeal space pleomorphic adenoma: a 30-year review.

Objectives/hypothesis: To evaluate the treatment results of pleomorphic adenoma (PA) of the parapharyngeal space at a single institution during a 30-year period.

Study Design: A retrospective review.

Methods: This study was performed by examining the records and reviewing the pathology of 44 patients with PA of the parapharyngeal space treated at a single medical center from January 1975 to November 2005.

Acellular dermal matrix grafts for prevention of microarterial thrombophlebitis.

Objective: To examine the role of acellular dermal matrix grafts for prevention of microarterial anastomotic thrombophlebitis.

Design: Bilateral femoral artery microvascular anastomoses were created in the field of established wounds infected with Staphylococcus aureus in 12 rats. In each animal, 1 femoral microarterial anastomosis was wrapped with an acellular dermal matrix graft, and the contralateral femoral anastomosis was left unprotected.

Adenoid cystic carcinoma of the submandibular gland: a 35-year review.

Objectives: To evaluate the treatment results of adenoid cystic carcinoma (ACC) of the submandibular gland at a single institution during a 35-year period.

Study Design & Setting: A retrospective review was performed by examining the records and reviewing the pathology of 22 patients with ACC of the submandibular gland treated at UCLA Medical Center from June 1963 to December 1997.

Results: Seven men and 15 women with an age range of 23 to 85 years (median, 48 years) were treated.

Analysis of outcome and complications in 400 cases of microvascular head and neck reconstruction.

Objective: To determine the incidence and causes of perioperative complications in patients who undergo microvascular free flap procedures for reconstruction of the head and neck.

Setting: Academic tertiary care medical center.

Patients And Methods: A total of 400 consecutive microvascular free flap procedures were performed for reconstruction of the head and neck, with 95% of the defects arising after the treatment of malignancies.

Fluorescence in situ hybridization for detecting TP16 MTS1/CDK41 gene deletions in squamous cell carcinoma of the head and neck.

We have previously shown TP16 MTS1/CDK41 gene deletion in more than 50% of a cohort of squamous cell carcinoma of the head and neck (SCCHN) patients using polymerase chain reaction (PCR). We have performed fluorescence in situ hybridization (FISH) on paraffin-embedded SCCHN specimens from the same cohort to identify the deletion of TP16 MTS1/CDK41CDK41gene. Twenty normal and 19 SCCHN specimens were studied.

Long-term survival outcome in transhyoid resection of base of tongue squamous cell carcinoma.

Background: The transhyoid approach for the resection of squamous cell carcinoma (SCC) of the base of the tongue continues to evolve and remains controversial. We previously reported that the functional outcome of this operation is superior to that of the traditional transmandibular approaches.

Objective: To report our long-term survival rates for T1, T2, and select T3 SCCs of the base of the tongue using the transhyoid approach.

The role of radiation in the treatment of advanced juvenile angiofibroma.

Objectives/hypothesis: To demonstrate the efficacy of external beam radiation therapy as a primary treatment modality for the management of patients with advanced juvenile nasopharyngeal angiofibroma (JNA).

Study Design: Retrospective chart review.

Methods: The medical records of 130 patients with the diagnosis of JNA seen at UCLA Medical Center over a 41-year period (1960-2000) were retrospectively reviewed.

Fungal mucoceles of the sphenoid sinus.

Objective: The purpose of this study was to demonstrate that fungal mucoceles of the sphenoid sinus do not necessarily require an external approach for eradication of disease. We report 6 cases of fungal mucoceles of the sphenoid sinus seen at UCLA Medical Center from 1980-1999, 4 of which were successfully treated with endoscopic intranasal sphenoidotomy and the other 2 through either a transseptal or transantral approach.

Study Design And Methods: Case series.

Cyclin D1 amplification and p16(MTS1/CDK4I) deletion correlate with poor prognosis in head and neck tumors.

Objectives/hypothesis: Cyclin D1, a cell cycle regulator localized to chromosome 11q13, is amplified in several human tumors including head and neck squamous cell carcinoma (HNSCC). Amplification and/or overexpression of cyclin D1 have been correlated to a poor prognosis. Deletion of the p16 gene, localized to 9p21, has also been observed in a significant proportion of HNSCC.

Nd:YAG laser therapy for palliation of recurrent squamous cell carcinomas in the oral cavity.

Background And Objectives: The objective of this study was to evaluate the outcome of laser photo-thermoablation for palliation of recurrent squamous cell tumors of the oral cavity.

Study Design/patients And Methods: Seventeen patients were treated with the Nd:YAG laser (power output was 50 W) delivered through a curved oral handpiece.

Results: Ten patients are alive, 7 with tumor remission, and 3 with persistent disease with an average follow-up of 16 months (range = 2-36).

Microvascular reconstruction after previous neck dissection.

Background: Microvascular reconstruction of defects in the head and neck is more challenging in patients who have undergone a previous neck dissection, owing to prior resection of potential cervical recipient blood vessels used for free flap perfusion.

Objective: To evaluate the reliability and safety of free flap reconstruction in patients with previous neck dissection.

Patients And Methods: Sixty free flaps were performed in 59 patients with a medical history of neck dissection for head and neck cancer.