Univariate and multivariate analysis of risk factors for severe Clostridium difficile-associated diarrhoea: importance of co-morbidity and serum C-reactive protein.

Aim: To investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients.

Methods: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review.

Results: Severe CDAD was present in 27 patients (22%).