Publications by authors named "Thomas Benkler"
Article Synopsis
- JAK2V617F(+) myeloproliferative neoplasms (MPNs) can turn into leukemias, and this study investigates the role of the Hedgehog (HH) signaling pathway in this progression.
- The loss of the PTCH2 gene, combined with excessive HH ligand production, leads to changes in blood cell production, resulting in symptoms such as increased white blood cell counts and organ enlargement.
- Targeting HH signaling with potential inhibitors may provide therapeutic avenues to stop MPNs from transforming into more aggressive leukemias.
