Publications by authors named "Thomas Balezeau"
Purpose: Female breast cancer (BC) patients exposed to gonadotoxic chemotherapy are at risk of future infertility. There is evidence of disparities in the discussion of fertility preservation for these patients. The aim of the study was to identify factors influencing the discussion of fertility preservation (FP).
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- This study compares the prognostic performance of two cancer assessment scores, Residual Cancer Burden (RCB) and Neo-Bioscore, in 750 women with invasive breast cancer who received neoadjuvant chemotherapy.
- The analysis found that RCB was generally more effective than Neo-Bioscore in predicting disease-free and overall survival, particularly in triple-negative breast cancer, although both scores were associated with patient outcomes.
- Adding factors like lymphovascular invasion and pre-/post-neoadjuvant chemotherapy tumor-infiltrating lymphocytes improved the performance of both scoring systems, but RCB's simpler classification system makes it easier to apply in clinical settings.
Tobacco use is associated with an increase in breast cancer (BC) mortality. Pathologic complete response (pCR) rate to neoadjuvant chemotherapy (NAC) is influenced by tumor-infiltrating lymphocyte (TIL) levels and is associated with a better long-term survival outcome. The aim of our study is to evaluate the impact of smoking status on TIL levels, response to NAC and prognosis for BC patients.
View Article and Find Full Text PDFPurpose: To apply text mining (TM) technology on electronic medical records (EMRs) of patients with breast cancer (BC) to retrieve the occurrence of a pregnancy after BC diagnosis and compare its performance to manual curation.
Materials And Methods: The training cohort (Cohort A) comprised 344 patients with BC age ≤ 40 years old treated at Institut Curie between 2005 and 2007. Manual curation consisted in manually reviewing each EMR to retrieve pregnancies.
Purpose: Few studies evaluated the prognostic value of the presence of lymphovascular invasion (LVI) after neoadjuvant chemotherapy (NAC) for breast cancer (BC).
Methods: The association between LVI and survival was evaluated in a cohort of BC patients treated by NAC between 2002 and 2011. Five post-NAC prognostic scores (ypAJCC, RCB, CPS, CPS + EG and Neo-Bioscore) were evaluated and compared with or without the addition of LVI.